Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity

Bouatia-Naji, Nabila; Vatin, Vincent; Lecoeur, Cécile; Heude, Barbara; Proença, Christine; Veslot, Jacques; Jouret, Béatrice; Tichet, Jean; Charpentier, Guillaume; Marre, Michel; Balkau, Beverley; Froguel, Philippe; Meyre, David

doi:10.1186/1471-2350-8-44

Table 2 Obesity and T2D case control analyses for SGNE1 SNPs. OR: odds ratio. ORs and p values are for allele frequencies comparisons. χ² test and the p values were computed with De Finetti program [17]. All obese cases are the pooled sample of obese children and severely obese adults.

From: Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity

	Genotype Frequencies			Allele Frequencies		OR [95%CI] (p value)
-1839 A>T rs13850	AA	AT	TT	A	T
Obese Children	384	128	21	0.84	0.16	1.10 [0.90–1.34] (0.335)
Severely obese adults	475	164	20	0.85	0.15	1.06 [0.88–1.28] (0.515)
All obese	859	292	41	0.84	0.16	1.08 [0.92–1.26] (0.327)
Type 2 Diabetes	777	306	20	0.84	0.16	1.08 [0.92–1.26] (0.339)
Controls	950	335	25	0.85	0.15
-1,701 A>G rs11635997	AA	AG	GG	A	G
Obese Children	191	267	90	0.59	0.41	1.14 [0.98–1.31] (0.078)
Severely obese adults	266	322	101	0.62	0.38	1.01 [0.88–1.16] (0.837)
All obese	457	589	191	0.61	0.39	1.07 [0.95–1.20] (0.255)
Type 2 Diabetes	554	722	208	0.62	0.38	1.03 [0.92–1.15] (0.619)
Controls	496	618	178	0.62	0.38
-706 C>G rs12595007	CC	CG	GG	C	G
Obese Children	384	111	10	0.87	0.13	0.83 [0.67–1.10] (0.081)
Severely obese adults	439	170	10	0.85	0.15	1.01 [0.84–1.21] (0.930)
All obese	823	281	20	0.86	0.14	0.92 [0.79–1.26] (0.343)
Type 2 Diabetes	976	352	21	0.85	0.15	0.95 [0.82–1.10] (0.511)
Controls	970	357	28	0.85	0.15
-304 A>G	AA	AG	GG	A	G
Obese Children	445	59	5	0.93	0.07	1.13 [0.84–1.51] (0.402)
Severely obese adults	587	91	2	0.93	0.07	1.17 [0.90–1.52] (0.240)
All obese	1032	150	7	0.93	0.07	1.15 [0.92–1.44] (0.210)
Type 2 Diabetes	1187	145	3	0.94	0.06	0.93 [0.74–1.17] (0.555)
Controls	1194	151	6	0.94	0.06
IVS3 -13,276 T>C rs1406387	TT	TC	CC	T	C
Obese Children	218	239	93	0.61	0.39	1.00 [0.86–1.15] (0.996)
Severely obese adults	243	340	102	0.60	0.40	1.05 [0.91–1.19] (0.510)
All obese	461	579	195	0.61	0.39	1.02 [0.92–1.14] (0.664)
Type 2 Diabetes	552	729	251	0.60	0.40	1.06 [0.96–1.18] (0.234)
Controls	499	666	191	0.61	0.39
IVS3-9,221 A>G rs8037112	AA	AG	GG	A	G
Obese Children	219	233	91	0.62	0.38	0.96 [0.83–1.11] (0.606)
Severely obese adults	260	322	95	0.62	0.38	0.95 [0.82–1.08] (0.422)
All obese	479	555	186	0.62	0.38	0.97 [0.85–1.07] (0.408)
Type 2 Diabetes	525	669	209	0.61	0.39	0.98 [0.88–1.10] (0.774)
Controls	481	666	190	0.61	0.39
IVS3 -3,045 A>C rs7170561	AA	AC	CC	A	C
Obese Children	248	211	66	0.67	0.33	1.04 [0.89–1.21] (0.621)
Severely obese adults	318	282	79	0.68	0.32	1.03 [0.89–1.18] (0.541)
All obese	566	493	145	0.67	0.33	1.03 [0.92–1.16] (0.598)
Type 2 Diabetes	627	603	155	0.67	0.33	1.05 [0.94–1.18] (0.372)
Controls	611	586	129	0.68	0.32
IVS3-2,058 A>Grs28688414	AA	AG	GG	A	G
Obese Children	307	184	33	0.76	0.24	1.00 [0.85–1.19] (0.959)
Severely obese adults	394	241	44	0.76	0.24	1.02 [0.88–1.19] (0.750)
All obese	701	425	77	0.76	0.24	1.01 [0.89–1.15] (0.809)
Type 2 Diabetes	803	480	94	0.76	0.24	1.03 [0.91–1.16] (0.678)
Controls	778	499	71	0.76	0.24
IVS3 +823 A>T rs12442397	AA	AT	TT	A	T
Obese Children	249	215	70	0.67	0.33	1.14 [0.98–1.32] (0.094)
Severely obese adults	320	293	64	0.69	0.31	1.03 [0.89–1.18] (0.670)
All obese	569	508	134	0.68	0.32	1.08 [0.96–0.1.21] (0.217)
Type 2 Diabetes	720	619	166	0.68	0.32	1.05 [0.94–1.18] (0.347)
Controls	642	583	117	0.70	0.30
IVS3 +881 A>C rs12438604	AA	AC	CC	A	C
Obese Children	323	184	35	0.77	0.23	1.16 [0.98–1.38] (0.073)
Severely obese adults	416	238	27	0.79	0.21	1.04 [0.89–1.22] (0.630)
All obese	739	422	62	0.78	0.22	1.09 [0.96–1.25] (0.181)
Type 2 Diabetes	903	463	81	0.78	0.22	1.05 [0.92–1.19] (0.459)
Controls	842	450	55	0.79	0.21
IVS4 +2,853 A>T rs11638903	AA	AT	TT	A	T
Obese Children	286	199	61	0.71	0.29	0.98 [0.84–1.15] (0.822)
Severely obese adults	335	291	56	0.70	0.30	0.99 [0.86–1.14] (0.885)
All obese	621	490	117	0.71	0.29	0.98 [0.87–1.11] (0.822)
Type 2 Diabetes	703	615	128	0.70	0.30	1.02 [0.91–1.14] (0.772)
Controls	657	588	109	0.70	0.30
IVS4 +1,514 G>C rs12592208	GG	GC	CC	G	C
Obese Children	281	195	65	0.70	0.30	0.96 [0.82–1.11] (0.591)
Severely obese adults	313	289	58	0.69	0.31	0.99 [0.85–1.14] (0.873)
All obese	594	484	123	0.70	0.30	0.97 [0.86–1.10] (0.678)
Type 2 Diabetes	716	647	139	0.69	0.31	0.99 [0.89–1.11] (0.911)
Controls	616	579	116	0.69	0.31

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