Figure 4

Schematic overview of the exon 52–62 duplication. Original and duplicated exons are shown in blue and red, respectively. The exon 52–62 duplication is located between exons 63 and 64 and therefore only the multiexon skip of the duplicated exons will restore the wild type transcript, whereas multiexon skipping of the original exon 52–62 will result in out-of-frame transcripts (upper and lower panel, respectively). Restoration of the reading frame can be achieved by skipping the duplicated exons 52 and 62, or the original exons 62, 63 combined with the duplicated exons 52 and 62 (middle panel). Note that skipping of the original exon 52 or exon 62 disrupts the open-reading-frame (lower panel).