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Table 4 Causes of death according to COMT genotypes

From: The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study

  Met/Met (n = 951) Met/Val (n = 1482) Val/Val (n = 546) Val/Val vs. other genotypes
  n % n % n % Log-rank p value
Neoplasms (C00-D48) 35 3.7 52 3.5 18 3.3 0.74
Cancers in the digestive system (C00-C26) 14 1.5 14 0.9 4 0.7 0.39
Cancer in the respiratory system (C30-C39) 6 0.6 11 0.7 1 0.2 0.23
Breast cancer/cancer in female genital organs (C50-C58) 2 0.2 2 0.1 1 0.2 1.00
Prostate cancer (C61) 5 0.5 10 0.7 6 1.1 0.24
All other neoplasms 8 0.8 15 1.0 6 1.1 0.92
Cardiovascular causes (I00-I99) 58 6.1 92 6.2 32 5.9 0.77
Ischemic heart diseases (I20-I25) 29 3.0 43 2.9 15 2.7 0.78
Non-ischemic heart diseases (I30-I33 and I39-I52)# 12 1.3 20 1.3 2 0.4 0.06
Cerebrovascular diseases (I60-I69) 10 1.1 19 1.3 9 1.6 0.39
All other vascular deaths 7 0.7 10 0.7 6 1.1 0.33
Sudden death (R96) 1 0.1 3 0.2 1 0.2 0.92
Accidents (V01-V99, W00-W99, and X00-X99) 7 0.7 10 0.7 5 0.9 0.87
Dementia (F03, G30, and R54) 7 0.7 6 0.4 1 0.2 0.49
Diseases of the respiratory system (J00-J99) 12 1.3 13 0.9 5 0.9 0.95
Diseases of the digestive system (K00-K93) 3 0.3 7 0.5 4 0.7 0.33
Diseases of the kidney and ureter (N00-99) 3 0.3 5 0.3 0 0 0.31
Other diseases* 3 0.3 9 0.6 3 0.5 0.87
  1. # Non-ischemic heart diseases (I30-I33 and I39-I52): Underlying cause of death among 34 individuals.
  2. Additionally, immediate cause of death among 28 others (in total 62 individuals)
  3. * Infections (A00-B99), diseases of the nervous system (G00-G99), mental and behavioral disorders (F00-F99), and other symptoms, sign, abnormal findings, ill-defined causes (R00-R94).