Table 2 Clinical characteristics of the subjects according to COMT genotypes.
Characteristics | No COMT genotyping (n = 62,247) | Met/Met (n = 951) | Met/Val (n = 1482) | Val/Val (n = 546) |
|---|---|---|---|---|
Sex, female (%) | 53.2 | 54.0 | 55.1 | 55.1 |
Age, mean (SD) | 49.1(18.9)$ | 52.8 (18.3) | 52.7 (18.2) | 52.1 (18.0) |
Education > 12 years (%) | 19.0 | 17.4 | 15.7 | 16.7 |
Mean systolic blood pressure (mmHg)(SD) | 137.6 (22.3)$ | 140.9 (22.2) | 140.4 (22.6) | 141.6 (22.9) |
Mean diastolic blood pressure (mmHg)(SD) | 80.2 (12.5)$ | 81.7 (12.4) | 81.0 (12.6) | 82.3 (12.9) |
Body mass index, kg/m2 (SD) | 26.4 (4.1) | 26.3 (4.2) | 26.4 (4.1) | 26.3 (4.2) |
Cholesterol, mmol (SD) | 5.89(1.26)$ | 6.02 (1.31) | 6.03 (1.30) | 6.08 (1.37) |
Current smoking (%) | 29.0 | 28.0 | 29.6 | 29.0 |
High level of physical activity* (%) | 24.1 | 19.9 | 18.7 | 20.1 |
Coffee intake > 6 cups/day (%) | 20.1 | 19.6 | 18.6 | 19.0 |
Use of antihypertensive medication (%) | 11.0 | 12.6 | 13.3 | 11.2 |
Myocardial infarction (%) | 3.3 | 3.7 | 3.5 | 2.8 |
Angina pectoris (%) | 5.0 | 6.9 | 7.1 | 5.9 |
Stroke (%) | 1.9 | 2.5 | 1.6 | 1.8 |