The genetic study of three population microisolates in South Tyrol (MICROS): study design and epidemiological perspectives

Table 3 Probability of Familial Clustering: Monte Carlo simulated p-values for some selected traits in the three microisolates separately and on the pooled data

Traits	Stelvio	Martello	Vallelunga	Pooled data
Symptoms for cardiovascular disease
Elevated Blood Pressure	0.0157	0.0035	0.0006	< 0.0001
Cardiac Arrhythmias	0.0651	0.0213	0.5690	0.0295
Angina pectoris	0.0005	0.6729	0.2500	0.0061
Cardiac Disease	0.0026	0.2319	0.0138	0.0000
Myocardial Infarction	0.6235	0.0003	0.2571	0.0000
Heart Defects	0.0016	0.6294	0.0279	0.0048
Neurological traits
Vertigo	0.0258	0.1831	0.2167	0.1750
Migraine	< 0.0001	0.3916	0.0005	< 0.0001
Carpal Tunnel Syndrome symptoms	0.0027	0.0303	0.0000	< 0.0001
Restless Leg's Syndrome (RLS)	0.0109	0.0646	0.0008	< 0.0001
Vascular Problems in the Carotid Arteries	0.0027	0.0006	0.0025	< 0.0001
Stroke	0.3660	0.0180	0.2482	0.0059
Epilepsy	0.0427	0.7504	0.8637	0.1561
Symptoms related to the respiratory system, allergy and dermatology
Asthma	0.0001	0.0005	0.6379	< 0.0001
Chronic Bronchitis	0.0133	0.0396	0.4507	0.0007
Hay Fever	0.1542	0.0207	0.1592	0.0916
Insect Hypersensitivity	0.0863	0.0237	0.2724	0.0620
Eczema	0.4639	0.0138	0.0012	0.0011
Psoriasis	0.0118	1.0000	0.3600	0.0148
Other traits
Diabetes	0.0001	0.0003	0.5314	< 0.0001
Goitre	0.0605	0.1413	0.0420	0.0639
Gout or Hyperuricemia	0.7653	0.0053	1.0000	0.0184
Gallbladder Disease	0.2856	0.4940	0.0535	0.3141
Ulcer	0.0616	0.0010	0.0001	< 0.0001
Liver Disease	0.6466	0.0050	0.0144	0.0163
Kidney Disease	0.9723	0.3993	0.2123	0.4940
Anemia	0.1978	0.0211	0.2789	0.0070

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