Table 2 Genotype distributions and estimates for the polymorphisms -1044 C>A and -920 A>C in the vicinity of SOCS3 for the case-control sample (percentages in parenthesis).
SOCS3 marker | underweight adults (n = 278) | extremely obese children and adolescents (n = 181) | estimated genotype odds ratio [exact 95% confidence interval] | estimated minor allele frequency in cases [Clopper- Pearson 95% confidence interval] |
|---|---|---|---|---|
-920 C>A | ||||
CC | 235 (84.53%) | 144 (79.56%) | ||
CA | 40 (14.39%) | 35 (19.34%) | 1.43 [0.84–2.42] | 10.77% [7.77%–14.43%] |
AA | 3 (1.08%) | 2 (1.10%) | 1.09 [0.09–9.61] | |
-1044 C>A | ||||
CC | 270 (97.12%) | 174 (96.13%) | ||
CA | 8 (2.88%) | 7 (3.87%) | 1.36 [0.41–4.37] | 1.93% [0.78%–3.94%] |
AA | 0 (0%) | 0 (0%) | - |