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Table 5 Associated phenotypes described for 13 candidate genes present on the heart rate QTL, mapped on SHR chromosome 8.

From: Genetic mapping of a new heart rate QTL on chromosome 8 of spontaneously hypertensive rats

Gene Name Associated phenotype Reference
Chrna3
Chrna5
Chrnb4
Cholinergic receptor, nicotinic, alpha polypeptide 3 and 5, and beta polypeptide 4 - Autonomic nervous system influence on heart rate;
- Alzheimer's disease;
- Autosomal dominant nocturnal frontal lobe epilepsy.
Bonati et al., 2000 [46]
Bonati et al., 2002 [47]
Duga et al., 2001 [43]
Kawamata et al., 2002 [48]
Lev-Lehman et al., 2001 [44]
Liang Y 2005 [49]
Rassadi, S 2005 [50]
Rempel et al., 1998 [45]
Wang et al., 2002 [51]
Wang et al., 2003 [52]
Hcn4 Hyperpolarization-activated, cyclic nucleotide – gated K+ 4 - Familial sinus bradycardia;
- Generation of pacemaker potentials in the sinoatrial node;
- Cardiac arrhythmia.
Leoni et al., 2005 [53]
Milanesi et al., 2006 [42]
Schulze-Bahr et al., 2003 [54]
Stieber et al., 2006 [55]
Stieber et al., 2003 [40]
Ueda et al., 2004 [41]
Htr3a
Htr3b
5-hydroxytryptamine (serotonin) receptor 3a and 3b - Modulatory role in the reflex control of the heart rate by cardiopulmonary receptors;
- Nausea induced by paroxetine;
- Fibromyalgia;
- Numerous human neuropsychiatric disorders (female major depression, bipolar affective and schizophrenic).
Aviado et al., 2001 [56]
Frank et al., 2004 [57]
Yamada et al., 2006 [58]
Iidaka et al., 2005 [59]
Niesler et al., 2001 [60]
Sevoz et al., 1997 [61]
Sugai et al., 2006 [62]
Thoren, 1979 [63]
Whalen et al., 2000 [64]
Scn2b Sodium channel, voltage-gated, type II, beta polypeptide - Essential hypertension;
- Liddle's syndrome;
- Idiopathic generalized epilepsy;
- Neuropathic pain;
- Cell adhesion and migration;
- Chronic Heart Failure.
Baker et al., 1998 [65]
Botero-Velez et al., 1994 [66]
Dong et al., 2002 [67]
Haug et al., 2000 [68]
Kim et al., 2005 [69]
Pegoraro RJ et al., 2004 [70]
Pertin et al., 2005 [71]
Schild et al., 1996 [72]
Snyder et al., 1995 [73]
Su et al., 1996 [74]
Rayner et al., 2003 [75]
Zicha S et al., 2004 [76]