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Table 4 Known genes present on the heart rate QTL mapped on SHR chromosome 8, and classified according to Gene Ontology (GO) terms.

From: Genetic mapping of a new heart rate QTL on chromosome 8 of spontaneously hypertensive rats

GO Terms Gene ID Description
Axon Bace1 beta-site APP cleaving enzyme 1
Metabolism Mpi_mapped mannose phosphate isomerase (mapped)
  Idh3a isocitrate dehydrogenase 3 (NAD+) alpha
  Man2c1 mannosidase, alpha, class 2C, member 1
  Pkm2 pyruvate kinase, muscle
Metal Ion Binding Pts 6-pyruvoyl-tetrahydropterin synthase
  Fdx1 ferredoxin 1
  Cyp19 cytochrome P450, subfamily 19
  Cyp1a2 cytochrome P450, 1a2
  Cyp11a cytochrome P450, subfamily 11A
  Ireb2 iron-regulatory protein 2
  Isl2 insulin related protein 2
  Cox5a cytochrome c oxidase, subunit Va
Nucleus Cryab crystallin, alpha B
  Atm_mapped ataxia telangiectasia mutated homolog (human) (mapped)
Protein Folding/Processing Hspb2 heat shock 27 kD protein 2
  Hyou1 hypoxia up-regulated 1
  Pcsk7 proprotein convertase subtilisin/kexin, type 7
Protein Binding Mcam l-gicerin
  Thy1 thymus cell antigen 1, theta
  Usp2 ubiquitin specific protease 2
  Zbtb16 zinc finger and BTB domain containing 16
  Cul5 vasopressin-activated calcium-mobilizing receptor protein
  Rcn2 reticulocalbin 2
  Cd3d CD3 antigen delta polypeptide
  Tagln transgelin
Receptor/Transporter/Channel Activity Blr1 Burkitt lymphoma receptor 1
  Il10ra interleukin 10 receptor, alpha
  Neo1 neogenin
  Slc37a4 solute carrier family 37 (glycerol-6-phosphate transporter), member 4
  Fxyd2 FXYD domain-containing ion transport regulator 2
  Fxyd6 FXYD domain-containing ion transport regulator 6
  Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4
  Timm8b translocase of inner mitochondrial membrane 8 homolog b (yeast)
  Scamp2 secretory carrier membrane protein 2
  Scamp5 secretory carrier membrane protein 5
Synaptic Transmission Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5
  Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3
  Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4
  Scn2b sodium channel, voltage-gated, type II, beta polypeptide
  Htr3b 5-hydroxytryptamine (serotonin) receptor 3b
  Htr3a 5-hydroxytryptamine (serotonin) receptor 3a
  Ncam1 neural cell adhesion molecule 1
Transferase Activity Hmbs hydroxymethylbilane synthase
  Dlat dihydrolipoamide acetyltransferase
  Acat1 acetyl-coenzyme A acetyltransferase 1
  Clk3 CDC-like kinase 3
Other Terms Rps25 ribosomal protein s25
  Treh trehalase
  Pafah1b2 platelet-activating factor acetylhydrolase alpha 2 subunit (PAF-AH alpha 2)
  Apoa5 apolipoprotein A-V
  Tmprss5 transmembrane protease, serine 5 (spinesin)
  Il18 interleukin 18
  Crabp1_mapped cellular retinoic acid binding protein I (mapped)
  Psma4 proteasome (prosome, macropain) subunit, alpha type 4
  Cspg4 membrane-spanning proteoglycan NG2
  Ptpn9 protein tyrosine phosphatase, non-receptor type 9
  Sdfr1 stromal cell derived factor receptor 1
  Hexa hexosaminidase A
  Myo9a myosin IXA
  Ube4a ubiquitin conjugation factor E4 A
  Cd276 CD276 antigen
No Terms Phldb1 pleckstrin homology-like domain, family B, member 1
  Crgl2 olfactomedin-related protein
  Znf291 KIAA1454-like protein