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Table 2 Unadjusted associations between SNPs from surfactant protein A alleles (SFTPA1,SFTPA2) and respiratory symptomsa during the first year of life for white infants at risk for developing asthma. (CT and MA, 1998 – 2000)

From: Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes

   Persistent cough (days/year) (%) Wheeze (days/year) (%)
Characteristic n (%) 0 1 – 7 8 – 14 15 – 21 22 – 28 > 28 p-valueb 0 1 – 7 8 – 14 15 – 21 22 – 28 > 28 p-valueb
White infants N (%) 221 109 (49.3) 30 (13.6) 19 (8.6) 12 (5.4) 10 (4.5) 41 (18.6)   119 (54.3) 49 (22.4) 17 (7.8) 7 (3.2) 6 (2.7) 21 (9.6)  
SFTPA1 c                
   aa 19 (rs1059047)                
CC 1 (0.4)               
CT 42 (19.0) 46.5 7.0 11.6 7.0 2.3 25.6 0.15 44.2 18.6 11.6 4.6 7.0 14.0 0.02
TT 178 (80.5) 49.7 14.9 8.0 5.1 5.1 17.1   56.6 23.1 6.9 2.9 1.7 8.7  
   aa 50 (rs1136450)                
CC 48 (21.4)               
CG 103 (46.0) 51.7 10.9 8.2 6.1 3.4 19.7 0.50 53.4 22.6 8.9 2.7 3.4 8.9 0.51
GG 73 (32.6) 45.2 17.8 9.6 4.1 6.8 16.4   55.6 22.2 5.6 4.2 1.4 11.1  
   aa 62 (rs1136451)                
GG 5 (2.2)               
AG 61 (27.5) 45.3 7.8 14.1 6.2 3.1 23.4 0.11 46.9 21.9 10.9 3.1 6.2 10.9 0.07
AA 156 (70.3) 51.3 15.6 6.5 4.6 5.2 16.9   57.9 21.7 6.6 3.3 1.3 9.2  
   aa 133 (rs1059057)                
GG 1 (0.4)               
AG 38 (16.9) 36.8 7.9 13.2 7.9 2.6 31.6 0.02 39.5 18.4 10.5 5.3 10.5 15.8 0.003
AA 186 (82.7) 51.9 14.8 7.6 4.9 4.9 15.8   57.5 23.2 7.2 2.8 1.1 8.3  
   aa 219 (rs4253527)                
TT 1 (0.4)               
CT 34 (15.1) 52.9 11.8 20.6 2.9 0.0 11.8 0.12 55.9 29.4 11.8 0.0 0.0 2.9 0.06
CC 190 (84.4) 48.7 13.9 6.4 5.9 5.4 19.8   54.0 21.1 7.0 3.9 3.2 10.8  
   SFTPA2 c                
aa 9 (rs1059046)                
CC 42 (18.7)               
AC 109 (48.4) 52.4 11.6 9.5 4.1 3.4 19.0 0.26 55.1 21.1 8.8 2.0 3.4 9.5 0.50
AA 74 (32.9) 43.2 17.6 6.8 8.1 6.7 17.6   52.8 25.0 5.6 5.6 1.4 9.7  
   aa 91 (rs17886395)                
CC 3 (1.4)               
CG 57 (25.7) 50.8 8.5 10.2 5.1 3.4 22.0 0.33 54.2 18.6 6.8 3.4 8.5 8.5 0.23
GG 162 (73.0) 49.1 15.1 8.2 5.7 5.0 17.0   54.8 23.6 8.3 3.2 0.6 9.6  
   aa 140 (rs1965707)                
TT 13 (5.8)               
CT 87 (38.8) 53.1 15.3 8.2 2.0 2.0 19.4 0.15 53.1 24.5 10.2 3.1 2.0 7.1 0.24
CC 124 (55.4) 45.9 12.3 9.0 8.2 6.6 18.0   55.0 20.8 5.8 3.3 3.3 11.7  
   aa 223 (rs1965708)                
AA 7 (3.1)               
AC 71 (31.6) 54.0 11.8 9.2 2.7 4.0 18.4 0.27 55.3 23.7 9.2 4.0 1.3 6.6 0.18
CC 147 (65.3) 46.9 14.5 8.3 6.9 4.8 18.6   53.8 21.7 7.0 2.8 3.5 11.2  
  1. aN = 221 infants had data for persistent cough and N = 219 for wheeze during the first year of life. bp-values from test for trend: Cochran-Armitage exact test (1-sided). Minor homozygotes and heterozygous alleles were combined and compared to the dominant homozygous group. Significant p-values (p < 0.05) in bold-face type. c SNPs were in Hardy-Weinberg equilibrium. rs numbers are given in parentheses next to each amino acid.