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Figure 2 | BMC Medical Genetics

Figure 2

From: Analysis of meiotic recombination in 22q11.2, a region that frequently undergoes deletions and duplications

Figure 2

Pedigree-based recombination breakpoint map based on the typing of 62 polymorphic markers (38 designed for this study; CATCH markers) in 14 extensive families totaling 204 meiosis. We localized a total of 27 single recombination events. The 22q11.2 region is drawn to scale including the locations of the LCR22s (green boxes) and the position of the polymorphic markers used. Blue, red and white lines represent regions to where male (blue), female (red) and unknown sex (white) recombination breakpoints have been narrowed down. Genes TBX1 and CRKL that are implicated in the clinical manifestations of the del22q11.2 syndrome are shown, as is the IGL locus also mentioned in the text.

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