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Table 5 Association between CFL1 genotypes and spina bifida risk: Odds Ratio estimation by Logistic Regression

From: Association between CFL1gene polymorphisms and spina bifida risk in a California population

 

No. of Control (%)

No. of Spina Bifida (%)

Crude OR (95% CI)

Non-Hispanic White OR (95% CI)

Hispanic White OR (95%CI)

rs652021

     

TT

102 (30.6)

55 (22.5)

ref

Ref

ref

TC

154 (46.3)

122 (49.8)

1.5 (0.9, 2.2)

1.1 (0.6, 2.0)

1.8 (0.9, 3.7)

CC

77 (23.1)

68 (27.8)

1.6 (1.0, 2.6)

2.8 (1.2, 6.5)

1.7 (0.8, 3.6)

rs4621

     

AA

104 (31.3)

57 (23.4)

ref

Ref

ref

AG

151 (45.5)

119 (48.8)

1.4 (0.9, 2.2)

1.1 (0.6, 2.0)

1.7 (0.9, 3.5)

GG

77 (23.2)

68 (27.9)

1.6 (1.0, 2.6)

2.8 (1.2, 6.5)

1.6 (0.8, 3.3)

rs11227332

     

AA

224 (76.7)

162 (69.2)

ref

ref

ref

AG

61 (20.9)

58 (24.8)

1.3 (0.9, 2.0)

1.3 (0.7, 2.4)

1.6 (0.8, 3.0)

GG

7 (2.4)

14 (6.0)

2.8 (1.1, 7.0)

5.1 (1.3, 20.2) §

2.8 (0.6, 14.4)

rs665306

     

CC

98 (30.1)

57 (23.7)

ref

ref

ref

CT

151 (46.3)

117 (48.6)

1.3 (0.9, 2.0)

1.0 (0.6, 1.9)

1.9 (0.9, 3.8)

TT

77 (23.6)

67 (27.8)

1.5 (0.9, 2.4)

2.3 (1.0, 5.2)

1.7 (0.8, 3.5)

rs667555

     

GG

96 (30.1)

55 (23.1)

Ref

Ref

ref

GT

148 (46.4)

122 (51.3)

1.4 (0.9, 2.2)

1.1 (0.6, 2.0)

1.9 (0.9, 4.0)

TT

75 (23.5)

61 (25.6)

1.4 (0.9, 2.3)

2.2 (0.9, 5.5)

1.6 (0.7, 3.4)

  1. OR: Odds Ratio; 95% CI: Wald 95% Confidence Interval;
  2. §: The smallest cell n = 3, Fisher Exact p = 0.01.