Skip to main content

Table 5 Case-control, TDT and FBAT (additive model) analyses of SNP C419A (A111E) at the GLO1 locus.

From: Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1

CASE-CONTROL

ITALIAN PATIENTS (N = 191)

ITALIAN CONTROLS (N = 171)

U.S. PATIENTS (N = 101)

  

ITALIAN PATIENTS (chr N = 382)

ITALIAN CONTROLS (chr N = 342)

U.S. PATIENTS (chr N = 202)

A/A

67 (35.1%)

52 (30.4%)

34 (33.7%)

 

A

221 (.5785)

186 (.5439)

115 (.5693)

A/C

87 (45.5%)

82 (48.0%)

47 (46.5%)

 

C

161 (.4215)

156 (.4561)

87 (.4307)

C/C

37 (19.4%)

37 (21.6%)

20 (19.8%)

     
 

Italian patient vs control genotypes χ2 = 0.94, 2 df, P = 0.63

Italian patient vs control alleles χ2 = 0.88, 1 df, P = 0.36

TDT

Autistic Patients

Unaffected Siblings

 

N = 236 complete trios

N = 100 complete trios

Maternal transmissions

Paternal transmissions

A Transmitted

105

χ2= 0.074(1df)

P = 0.79

56

χ2= 4.35(1df)

P < 0.05

21

χ2= 1.00(1df),

P = 0.32

26

χ2 = 5.16(1df),

P < 0.05

C Transmitted

109

 

36

 

15

 

12

 

TDT autistic patients vs unaffected siblings: χ2 = 24.48 (1df), P < 0.000001

FBAT

Allele

N. of families

S

E(S)

Var(S)

Z

P

Autistic Patients

A

170

199.000

206.000

61.500

-0.893

0.37

  

C

170

189.000

182.000

61.500

0.893

 

Unaffected Siblings

A

77

111.000

103.000

30.000

1.461

0.14

  

C

77

75.000

83.000

30.000

-1.461

 

FBAT autistic patients vs unaffected siblings: Z = 17.44, P < 0.00001