Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1

Table 2 TDT and FBAT analyses of SNPs rs4570625 and rs4565946, and relative haplotypes at the TPH2 locus.*

TDT	TPH2 – RS4570625		TPH2 – rs4565946			HAPLOTYPES RS4570625-RS4565946
	N = 224 complete trios		N = 219 complete trios			Haplotype	T	NT	χ ² (1df)	P-value
G Transmitted	88	χ² = 1.21(1 df), P = 0.27	C Transmitted	107	χ² = 0.57(1 df), P = 0.45	G-C	73	72	0.01	0.92
T Transmitted	77		T Transmitted	116		G-T	87	74	1.05	0.31
						T-C	51	63	1.26	0.26
						T-T	1	3	1.00	0.32
*FBAT*	Allele	N. of families	S	E(S)	Var(S)	Z	P
rs4570625	G	136	194.000	188.000	42.000	0.926	0.35
	T	136	84.000	90.000	42.000	-0.926
rs4565946	C	166	161.000	165.500	57.750	-0.592	0.55
	T	166	183.000	178.500	57.750	0.592
Haplotypes (Estimated Freq)
G-T (0.486)		160.9	195.112	190.637	56.686	0.594	0.55
G-C (0.296)		154.0	127.888	126.863	48.312	0.147	0.88
T-C (0.211)		125.4	78.112	83.137	39.218	-0.802	0.42
T-T (0.008)		6.7	-	-	-	-	-

*FBAT analyses are performed under an additive model [29,30]. P-values are rounded to the second digit.

ISSN: 1471-2350