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Figure 3 | BMC Medical Genetics

Figure 3

From: Coarctation of the aorta and mild to moderate developmental delay in a child with a de novo deletion of chromosome 15(q21.1q22.2)

Figure 3

Fluorescence in situ hybridization (FISH) of 15q21.1q22.2 region using BAC probes. (A) Hybridization with clones RP11-231A23 (green; distal to the deletion interval) and RP11-105D1 (red) showing deletion of one copy of RP11-105D1. (B) Deletion of one copy of RP11-23N2 (red) hybridized with centromeric control probe (green). (C) Hybridization with RP11-50C13 (green) and RP11-485O10 (red; proximal to the deletion boundary) showing deletion of one copy of RP11-50C13. (D) Hybridization with RP11-69G7 (red) encompassing α-tropomyosin gene, shows intact alleles on both chromosomes.

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BMC Medical Genetics

ISSN: 1471-2350

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