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Table 1 Data collected from participants in GS:SFHS

From: Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability

1. Pre-clinic questionnaire

a. Demographic details

b. Occupational history

c. Lifestyle – smoking, alcohol, diet, exercise and participation in sports

d. Personal and family medical history

e. Rose angina questionnaire

f. Musculoskeletal questions – including chronic pain, fractures, joint replacements, HRT use, age at

menarche and menopause

g. Current drug history, including prescribed and some non-prescribed,

2. Physical measurements

a. Height, weight

b. Blood Pressure × 2, resting pulse

c. Ankle brachial pressure index

d. Spirometry

e. Electrocardiograph

f. Bioimpedance

3. Personality, Cognitive function, and Psychological distress measurements

a. Eysenck Personality Questionnaire Revised Short Form[27]

b. Logical Memory from the Wechsler Memory Scale III[28]

c. Digit Symbol from the Wechsler Adult Intelligence Scale III[29]

d. Verbal Fluency[30]

e. Mill Hill Vocabulary Scale[31]

f. General Health Questionnaire-28[32]

4. Mental health measurements

a. SCID Brief screening interview for major depression[33]

5. Biological samples

a. Blood: EDTA for DNA – 2 × 4.7 ml, 1 × 9 ml;

Clot activator with gel separator for serum – 3 × 5 ml

Fluoride oxalate for glucose – 1 × 2 ml

b. Urine: Stored for future proteomics analysis