1. Pre-clinic questionnaire |
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a. Demographic details |
b. Occupational history |
c. Lifestyle – smoking, alcohol, diet, exercise and participation in sports |
d. Personal and family medical history |
e. Rose angina questionnaire |
f. Musculoskeletal questions – including chronic pain, fractures, joint replacements, HRT use, age at |
menarche and menopause |
g. Current drug history, including prescribed and some non-prescribed, |
2. Physical measurements |
a. Height, weight |
b. Blood Pressure × 2, resting pulse |
c. Ankle brachial pressure index |
d. Spirometry |
e. Electrocardiograph |
f. Bioimpedance |
3. Personality, Cognitive function, and Psychological distress measurements |
a. Eysenck Personality Questionnaire Revised Short Form[27] |
b. Logical Memory from the Wechsler Memory Scale III[28] |
c. Digit Symbol from the Wechsler Adult Intelligence Scale III[29] |
d. Verbal Fluency[30] |
e. Mill Hill Vocabulary Scale[31] |
f. General Health Questionnaire-28[32] |
4. Mental health measurements |
a. SCID Brief screening interview for major depression[33] |
5. Biological samples |
a. Blood: EDTA for DNA – 2 × 4.7 ml, 1 × 9 ml; |
Clot activator with gel separator for serum – 3 × 5 ml |
Fluoride oxalate for glucose – 1 × 2 ml |
b. Urine: Stored for future proteomics analysis |