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Table 3 Multipoint LOD score and chromosomal location in the Original, Follow-up and Combined samples are shown.

From: Genome-wide significance for a modifier of age at neurological onset in Huntington's Disease at 6q23-24: the HD MAPS study

A Model One LOD scores.

Chromosome Location

Original Sample

Follow-up Sample

Combined Sample

 

Distance *

(cM)

LOD

p-value

Distance *

(cM)

LOD

p-value

Distance *

(cM)

LOD

p-value

2q33

200

1.37

0.006

210

0.17

0.2

200

1.37

0.006

4p16

2

2.19

0.0007

0

0

0.5

0

1.94

0.0014

5q31-32

147

1.23

0.009

160

0.15

0.2

142

0.98

0.02

6p22.3

34

1.13

0.011

34

0.01

0.4

34

1.14

0.011

6q23-24

149

2.75

0.0002

142

1.87

0.002

149

4.05

0.00001

18q22

89

1.23

0.009

75

0.79

0.03

89

1.78

0.002

B Model Two LOD scores.

2q33

200

1.56

0.004

210

0.21

0.2

200

1.62

0.003

4p16

2

2.15

0.0008

0

0

0.5

0

1.9

0.002

5q31-32

147

1.27

0.008

160

0.12

0.2

147

0.98

0.02

6p22.3

34

0.88

0.02

34

0.01

0.4

34

0.95

0.02

6q23-24

148

3.5

0.00003

142

2.27

0.0006

149

4.94

<10-6

18q22

89

0.96

0.02

75

0.79

0.02

89

1.55

0.004

  1. A. Model One was used to adjust age at onset and age at onset was adjusted by HD repeats only; B. Model Two was used to adjust age at onset, and age at onset was adjusted by HD repeat, normal repeat and their interaction.
  2. * The genetic distances are as indicated by the Marshfield linkage map [26]
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BMC Medical Genetics

ISSN: 1471-2350

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