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Table 1 The Study Subjects.

From: Genome-wide significance for a modifier of age at neurological onset in Huntington's Disease at 6q23-24: the HD MAPS study

 

Original Sample

Follow-up Sample

Combined Sample

Pedigrees

295

69a

352

Sibling-pairs

629

102

753b

Patients

695

141

836

Mean Onset ± SD

39.3 ± 12.1

39.2 ± 11.8

39.3 ± 12.0

Mean HD repeat ± SD

46.4 ± 5.9

45.5 ± 5.5

46.2 ± 5.7

  1. Note (details provided in Subjects section of Materials and Methods):
  2. a57 pedigrees are newly recruited, and the remaining 12 are from the Original Sample with newly recruited siblings.
  3. bThe number of pairs in the Combined Sample exceeds that for the sum of the Original Sample and Follow-up Sample because additional sibling pairs (21 new sibling pairs and one half sib) were created when new siblings were added to existing pedigrees.