Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma

BMC Medical Genetics

Table 4 Estimated frequency distribution of surfactant protein A (SP-A) haplotypes among infants at risk for the development of asthma. Unadjusted odds ratios (OR) and 95% confidence intervals (CI) from logistic regression models^a of any episodes of otitis media before 12 months of age. (N = 226 white infants, CT and MA, 1998 – 2000.)

SP-A Haplotype^b	Estimated Frequency Distribution^c % (95% CI)	Any OM Episodes OR (95% CI)
6A/1A	5.4% (3.2 – 7.2)	2.13 (0.59, 7.68)
6A ² /1A ⁰	49.0% (44.4 – 53.6)	1.10 (0.53, 2.30)
6A ² /1A ²	1.8% (0.6 – 2.9)	1.71 (0.20, 14.4)
6A ² /1A ³	1.0% (0.2 – 1.9)	0.90 (0.09, 8.83)
6A ³ /1A ⁰	4.7% (2.8 – 6.6)	0.87 (0.29, 2.58)
6A ³ /1A ¹	11.3% (8.5 – 14.1)	0.70 (0.33, 2.47)
6A ³ /1A ²	5.6% (3.6 – 7.6)	0.90 (0.33, 2.47)
6A ³ /1A ⁶	1.7% (0.5 – 2.8)	0.73 (0.13, 4.01)
6A ⁴ /1A ⁵	2.9% (1.4 – 4.4)	0.23 (0.07, 0.73)
6A ⁴ /1A ⁶	1.8% (0.6 – 3.0)	0.46 (0.10, 2.09)
Others	14.9%

^aSeparate logistic regression analyses were performed for each outcome measure and each haplotype with all other haplotypes serving as the reference group in each model. All model results include estimates of model variability due to ambiguity in allele haplotype assignment (see "Data analysis" in text).
^bN = 217 infants with complete data for both SP-A1 and SP-A2 alleles.
^cEstimated frequency distribution of SP-A haplotypes (mean, 95% CI) for white infants.

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