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Table 4 Estimated frequency distribution of surfactant protein A (SP-A) haplotypes among infants at risk for the development of asthma. Unadjusted odds ratios (OR) and 95% confidence intervals (CI) from logistic regression modelsa of any episodes of otitis media before 12 months of age. (N = 226 white infants, CT and MA, 1998 – 2000.)

From: Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma

SP-A Haplotypeb Estimated Frequency Distributionc % (95% CI) Any OM Episodes OR (95% CI)
6A/1A 5.4% (3.2 – 7.2) 2.13 (0.59, 7.68)
6A 2 /1A 0 49.0% (44.4 – 53.6) 1.10 (0.53, 2.30)
6A 2 /1A 2 1.8% (0.6 – 2.9) 1.71 (0.20, 14.4)
6A 2 /1A 3 1.0% (0.2 – 1.9) 0.90 (0.09, 8.83)
6A 3 /1A 0 4.7% (2.8 – 6.6) 0.87 (0.29, 2.58)
6A 3 /1A 1 11.3% (8.5 – 14.1) 0.70 (0.33, 2.47)
6A 3 /1A 2 5.6% (3.6 – 7.6) 0.90 (0.33, 2.47)
6A 3 /1A 6 1.7% (0.5 – 2.8) 0.73 (0.13, 4.01)
6A 4 /1A 5 2.9% (1.4 – 4.4) 0.23 (0.07, 0.73)
6A 4 /1A 6 1.8% (0.6 – 3.0) 0.46 (0.10, 2.09)
Others 14.9%  
  1. aSeparate logistic regression analyses were performed for each outcome measure and each haplotype with all other haplotypes serving as the reference group in each model. All model results include estimates of model variability due to ambiguity in allele haplotype assignment (see "Data analysis" in text).
  2. bN = 217 infants with complete data for both SP-A1 and SP-A2 alleles.
  3. cEstimated frequency distribution of SP-A haplotypes (mean, 95% CI) for white infants.