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Table 3 Surfactant protein A (SP-A1 and SP-A2) allele haplotypesa and unadjusted odds ratios (OR) and 95% confidence intervals (CI) from logistic regression modelsb of any episodes of otitis media before 12 months of age. (CT and MA, 1998 – 2000)

From: Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma

Allele, haplotypec Nucleotide/amino acidd Estimated Frequency Distributione % (95% CI) Any OM Episodes OR (95% CI)
SP-A1 aa 19 aa 50 aa 62 aa 133 aa 219   
   6A C/Ala C/Leu G G C/Arg 6.1% (4.0 – 8.3) 1.96 (0.63, 6.10)
   6A 2 T/Val G/Val A A C/Arg 54.0% (49.3 – 58.7) 0.95 (0.44, 2.04)
   6A 3 T/Val C/Leu A A C/Arg 25.6% (21.6 – 29.6) 0.85 (0.45, 1.60)
   6A 4 T/Val C/Leu G A T/Trp 6.2% (4.1 – 8.4) 0.34 (0.15, 0.79)
   all others       8%  
SP-A2 aa 9 aa 91 aa 140 aa 223    
   1A C/Thr C/Pro C C/Gln   8.4% (6.0 – 10.8) 3.03 (0.88, 10.39)
   1A 0 A/Asn G/Ala C C/Gln   54.2% (49.5 – 58.8) 1.04 (0.48, 2.25)
   1A 1 C/Thr G/Ala T A/Lys   13.7% (10.7 – 16.7) 0.69 (0.34, 1.39)
   1A 2 C/Thr G/Ala C C/Gln   10.2% (7.6 – 12.7) 0.98 (0.43, 2.22)
   1A 3 A/Asn G/Ala T A/Lys   1.8% (0.7 – 2.9) 0.80 (0.15, 4.35)
   1A 5 C/Thr C/Pro T C/Gln   4.6% (2.7 – 6.5) 0.38 (0.14, 1.05)
   1A 6 C/Thr G/Ala T C/Gln   3.2% (1.7 – 4.7) 0.77 (0.20, 2.92)
   all others       4%  
  1. aN = 219 white infants with complete data for SP-A1 alleles and N = 222 white infants with complete data for SP-A2 alleles.
  2. bSeparate logistic regression analyses were performed for each outcome measure and each haplotype with all other haplotypes serving as the reference group in each model. All model results include estimates of model variability due to ambiguity in allele haplotype assignment (see "Data analysis" in text).
  3. cBy convention [ref Lofgren et al JID 2002;185:283-289], SP-A1 allele haplotypes are denoted by 6An and SP-A2 alleles by 1Am.
  4. dCodons aa62, aa133, and aa140 are silent.
  5. eEstimated frequency distribution of SP-A1 and SP-A2 haplotypes (mean, 95% CI) for white infants.