Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study

Table 8 Haplotype analyses for two HLA loci combined and stratified by population and sex

Population	Sex	Haplotype combination	Global Score Statistics	DF	p value	Most significant haplotype		Haplotype-specific score statistics^a	p value^a
						Haplotype	Population frequency (%)
Belgian
	Male	DQA1+DQB1	54.0	42	0.102	0102~0602	9.4	2.97	0.003
		DQA1+DRB1	57.8	53	0.303	0102~1601	10.5	3.50	0.001
		DQA1+DRB3-5	44.8	39	0.240	0102~B5-0101	9.4	2.95	0.003
		DQB1+DRB1	81.1	82	0.508	0602~1601	8.9	2.88	0.004
		DQB1+DRB3-5	53.5	60	0.710	0602~B5-0101	9.2	2.88	0.004
		DRB1+DRB3-5	84.5	81	0.374	1601~B5-0101	9.3	3.24	0.001
	Female	DQA1+DQB1	29.7	28	0.380	0102~0603	1.3	3.48	0.001
		DQA1+DRB1	41.6	34	0.173	0102~1301	2.1	3.52	0.001
		DQA1+DRB3-5	22.9	26	0.638	0501~B3-0201	0.6	2.12	0.033
		DQB1+DRB1	40.7	49	0.794	0604~1301	2.2	2.81	0.005
		DQB1+DRB3-5	38.0	37	0.422	0603~B5-0101	0.6	2.74	0.006
		DRB1+DRB3-5	49.4	48	0.418	1301~B3-0301	2.2	2.92	0.003
Canadian
	Male	DQA1+DQB1	27.6	32	0.691	0101~0201	0.3	-2.16	0.031
		DQA1+DRB1	36.8	38	0.527	0101~0102	0.8	-2.34	0.020
		DQA1+DRB3-5	27.8	33	0.724	0401~B5-0101	0.3	-2.00	0.046
		DQB1+DRB1	55.7	56	0.486	0501~0102	0.8	-2.22	0.027
		DQB1+DRB3-5	36.3	49	0.910	03032~B3-0301	1.1	-3.32	0.001
		DRB1+DRB3-5	55.6	63	0.735	0701~B4-0101	11.4	-2.19	0.028
	Female	DQA1+DQB1	29.1	31	0.563	0201~0302	1.2	2.01	0.045
		DQA1+DRB1	41.4	38	0.326	0103~1301	0.4	2.25	0.024
		DQA1+DRB3-5	34.1	33	0.414	0102~B3-0101	0.6	2.37	0.018
		DQB1+DRB1	69.6	62	0.237	0302~0407	0.5	2.71	0.007
		DQB1+DRB3-5	49.0	43	0.245	0602~B4-0101	0.9	2.93	0.003
		DRB1+DRB3-5	61.1	60	0.437	0301~B3-0301	0.2	2.37	0.017

DF: degrees of freedom; AAA: abdominal aortic aneurysm.
^a Haplo.stats program [29] was used for the analyses. Rare haplotype with frequencies ≤ 0.01 were pooled into a single baseline group. Results on haplotypes with only two loci are reported.

ISSN: 1471-2350