Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study

Ogata, Toru; Gregoire, Lucie; Goddard, Katrina AB; Skunca, Magdalena; Tromp, Gerard; Lancaster, Wayne D; Parrado, Antonio R; Lu, Qing; Shibamura, Hidenori; Sakalihasan, Natzi; Limet, Raymond; MacKean, Gerald L; Arthur, Claudette; Sueda, Taijiro; Kuivaniemi, Helena

doi:10.1186/1471-2350-7-67

Table 3 HLA-DRB1 allele frequencies in AAA cases and controls

From: Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study

	AAA Cases						Controls
	Male		Female		Total		Male		Female		Total
DRB1 alleles^a	n^b	%	n^b	%	n^b	%	n^b	%	n^b	%	n^b	%
Belgian
*0101	29	9.1	3	8.3	32	9.0	39	10.9	14	8.3	53	10.1
*0102	7	2.2	1	2.8	8	2.2	7	2.0	4	2.4	11	2.1
*0103	1	0.3	1	2.8	2	0.6	0	0	0	0	0	0
*0301/0303	5	1.6	1	2.8	6	1.7	7	2.0	9	5.4	16	3.0
*0302	22	6.9	2	5.6	24	6.7	27	7.5	8	4.8	35	6.7
*0401	11	3.4	3	8.3	14	3.9	20	5.6	10	6.0	30	5.7
*0402	1	0.3	0	0	1	0.3	1	0.3	2	1.2	3	0.6
*0403	7	2.2	2	5.6	9	2.5	13	3.6	5	3.0	18	3.4
*0404	9	2.8	0	0	9	2.5	10	2.8	6	3.6	16	3.0
*0405	0	0	0	0	0	0	4	1.1	0	0	4	0.8
*0407	2	0.6	0	0	2	0.6	2	0.6	1	0.6	3	0.6
*0408	0	0	0	0	0	0	1	0.3	0	0	1	0.2
*0410	1	0.3	0	0	1	0.3	0	0	0	0	0	0
*0413	3	0.9	0	0	3	0.8	1	0.3	1	0.6	2	0.4
*0701/0702	54	16.9	3	8.3	57	16.0	51	14.2	18	10.7	69	13.1
*0801	9	2.8	3	8.3	12	3.4	11	3.1	6	3.6	17	3.2
*0802	0	0	0	0	0	0	1	0.3	2	1.2	3	0.6
*0803	1	0.3	0	0	1	0.3	0	0	2	1.2	2	0.4
*0805	0	0	0	0	0	0	0	0	0	0	0	0
*0901	4	1.3	0	0	4	1.1	5	1.4	2	1.2	7	1.3
*1001	3	0.9	0	0	3	0.8	7	2.0	0	0	7	1.3
*1101	41	12.8	8	22.2	49	13.8	38	10.6	25	14.9	63	12.0
*1102	0	0	0	0	0	0	2	0.6	1	0.6	3	0.6
*1103	7	2.2	1	2.8	8	2.2	4	1.1	1	0.6	5	1.0
*1104	1	0.3	0	0	1	0.3	1	0.3	0	0	1	0.2
*1201	3	0.9	1	2.8	4	1.1	6	1.7	0	0	6	1.1
*1301	14	4.4	3	8.3	17	4.8	10	2.8	1	0.6	11	2.1
*1302	18	5.6	1	2.8	19	5.3	34	9.5	13	7.7	47	8.9
*1303	3	0.9	0	0	3	0.8	3	0.8	4	2.4	7	1.3
*1305	0	0	0	0	0	0	0	0	0	0	0	0
*1401	5	1.6	0	0	5	1.4	5	1.4	1	0.6	6	1.1
*1407	3	0.9	0	0	3	0.8	6	1.7	3	1.8	9	1.7
*1501	0	0	0	0	0	0	1	0.3	2	1.2	3	0.6
*1502	1	0.3	0	0	1	0.3	0	0	0	0	0	0
*1601	47	14.7	2	5.6	49	13.8	27	7.5	19	11.3	46	8.7
*1602	0	0	0	0	0	0	2	0.6	0	0	2	0.4
0301/0303 or 0302	1	0.3	0	0	1	0.3	2	0.6	3	1.8	5	1.0
0403 or 0407	0	0	0	0	0	0	1	0.3	1	0.6	2	0.4
0404 or 0408	0	0	0	0	0	0	0	0	1	0.6	1	0.2
1101 or 1104	0	0	0	0	0	0	0	0	0	0	0	0
1301 or 1302	7	2.2	1	2.8	8	2.2	5	1.4	2	1.2	7	1.3
1401 or 1407	0	0	0	0	0	0	2	0.6	1	0.6	3	0.6
CND	0	0	0	0	0	0	2	0.6	0	0	2	0.4
Total	320	100.0	36	100.0	356	100.0	358	100.0	168	100.0	526	100.0
Canadian
*0101	27	8.8	7	7.0	34	8.3	4	6.1	21	8.5	25	8.0
*0102	1	0.3	1	1.0	2	0.5	2	3.0	4	1.6	6	1.9
*0103	6	1.9	1	1.0	7	1.7	2	3.0	4	1.6	6	1.9
*0301/0303	13	4.2	2	2.0	15	3.7	3	4.5	7	2.8	10	3.2
*0302	26	8.4	12	12	38	9.3	2	3.0	23	9.3	25	8.0
*0401	31	10.0	8	8.0	39	9.6	6	9.1	28	11.3	34	10.8
*0402	2	0.6	0	0	2	0.5	0	0	0	0	0	0
*0403	8	2.6	7	7.0	15	3.7	3	4.5	7	2.8	10	3.2
*0404	17	5.5	4	4.0	21	5.1	3	4.5	11	4.4	14	4.5
*0405	0	0	0	0	0	0	0	0	2	0.8	2	0.6
*0407	1	0.3	2	2.0	3	0.7	0	0	0	0	0	0
*0408	1	0.3	0	0	1	0.2	0	0	0	0	0	0
*0410	0	0	0	0	0	0	0	0	0	0	0	0
*0413	0	0	0	0	0	0	0	0	0	0	0	0
*0701/0702	49	15.9	18	18	67	16.4	18	27.3	36	14.5	54	17.2
*0801	7	2.3	1	1.0	8	2.0	0	0	6	2.4	6	1.9
*0802	0	0	1	1.0	1	0.2	0	0	2	0.8	2	0.6
*0803	0	0	0	0	0	0	0	0	1	0.4	1	0.3
*0805	0	0	0	0	0	0	1	1.5	0	0	1	0.3
*0901	7	2.3	0	0	7	1.7	0	0	2	0.8	2	0.6
*1001	3	1.0	0	0	3	0.7	0	0	3	1.2	3	1.0
*1101	22	7.1	7	7.0	29	7.1	3	4.5	21	8.5	24	7.6
*1102	1	0.3	0	0	1	0.2	0	0	1	0.4	1	0.3
*1103	1	0.3	1	1.0	2	0.5	0	0	0	0	0	0
*1104	0	0	0	0	0	0	0	0	0	0	0	0
*1201	0	0	1	1.0	1	0.2	0	0	3	1.2	3	1.0
*1301	8	2.6	3	3.0	11	2.7	1	1.5	1	0.4	2	0.6
*1302	12	3.9	8	8.0	20	4.9	3	4.5	21	8.5	24	7.6
*1303	3	1.0	0	0	3	0.7	0	0	0	0	0	0
*1305	1	0.3	0	0	1	0.2	0	0	1	0.4	1	0.3
*1401	5	1.6	0	0	5	1.2	2	3.0	2	0.8	4	1.3
*1407	2	0.6	0	0	2	0.5	1	1.5	6	2.4	7	2.2
*1501	0	0	0	0	0	0	0	0	0	0	0	0
*1502	0	0	0	0	0	0	0	0	0	0	0	0
*1601	42	13.6	15	15	57	14.0	9	13.6	29	11.7	38	12.1
*1602	0	0	0	0	0	0	0	0	0	0	0	0
0301/0303 or 0302	4	1.3	0	0	4	1.0	1	1.5	2	0.8	3	1.0
0403 or 0407	1	0.3	0	0	1	0.2	0	0	0	0	0	0
0404 or 0408	0	0	1	1.0	1	0.2	0	0	0	0	0	0
1101 or 1104	1	0.3	0	0	1	0.2	0	0	0	0	0	0
1301 or 1302	4	1.3	0	0	4	1.0	1	1.5	1	0.4	2	0.6
1401 or 1407	1	0.3	0	0	1	0.2	1	1.5	2	0.8	3	1.0
CND	1	0.3	0	0	1	0.2	0	0	1	0.4	1	0.3
Total	308	100.0	100	100.0	408	100.0	66	100.0	248	100.0	314	100.0

AAA: abdominal aortic aneurysm; CND: could not be determined.
^a Alleles *0406, *0409, *0411, *0412, *0414, *0415, *0804, *0806, *1105, *1202, *1304, *1306, *1402, *1403, *1404, *1405, *1406, *1408, *1409,*1410 and *1503 were also assayed but were not present in either population.
^b Number of alleles.
^c Could be classified into two possible alleles, but could not be classified into one particular allele.

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