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Table 4 Haplotype TDT of CC chemokine gene cluster SNPs.

From: An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians

Haplotype Frequency Transmitted Non-transmitted χ2(1df) P (uncorrected)
(a) Local cohort
5' haplotype block
4-marker haplotypes
CCL2 -2581.CCL2 -2138.CCL11 -488.CCL11 67 (n = 162 trio families)
A.A.C.G 0.33 57.0 85.0 5.50 0.02
A.T.C.G 0.18 61.0 40.0 4.36 0.04
3-marker haplotypes
CCL2 -2581.CCL2 -2138.CCL11 -488 (n = 162 trio families)
A.A.C 0.33 56.0 86.0 6.33 0.01
A.T.C 0.18 61.0 40.0 4.36 0.04
CCL2 -2138.CCL11 -488.CCL11 67 (n = 162 trio families)
A.C.G 0.63 70.1 92.0 2.96 0.09
T.C.G 0.18 60.9 40.0 4.34 0.04
2-marker haplotypes
CCL2 -2581.CCL2 -2138 (n = 204 trio families)
A.A 0.52 89.1 117.1 3.80 0.05
CCL2 -2138.CCL11 -488 (n = 162 trio families)
A.C 0.62 69.2 93.1 3.50 0.06
T.C 0.18 60.8 39.9 4.32 0.04
(b) Independent cohort (n = 169 trio families)CCL2 -2138.CCL11 -488
A.C 0.63 75.1 86.0 0.74 0.4
T.C 0.20 59.9 52.0 0.56 0.5
(c) Combined dataset (n = 331 trio families) CCL2 -2138.CCL11 -488
A.C 0.62 144.4 179.1 3.73 0.05
T.C 0.19 120.6 91.9 3.89 0.05