|
(a) Local cohort
|
|
5' haplotype block
|
|
4-marker haplotypes
|
|
CCL2 -2581.CCL2 -2138.CCL11 -488.CCL11 67 (n = 162 trio families)
|
|
A.A.C.G
|
0.33
|
57.0
|
85.0
|
5.50
|
0.02
|
|
A.T.C.G
|
0.18
|
61.0
|
40.0
|
4.36
|
0.04
|
|
3-marker haplotypes
|
|
CCL2 -2581.CCL2 -2138.CCL11 -488 (n = 162 trio families)
|
|
A.A.C
|
0.33
|
56.0
|
86.0
|
6.33
|
0.01
|
|
A.T.C
|
0.18
|
61.0
|
40.0
|
4.36
|
0.04
|
|
CCL2 -2138.CCL11 -488.CCL11 67 (n = 162 trio families)
|
|
A.C.G
|
0.63
|
70.1
|
92.0
|
2.96
|
0.09
|
|
T.C.G
|
0.18
|
60.9
|
40.0
|
4.34
|
0.04
|
|
2-marker haplotypes
|
|
CCL2 -2581.CCL2 -2138 (n = 204 trio families)
|
|
A.A
|
0.52
|
89.1
|
117.1
|
3.80
|
0.05
|
|
CCL2 -2138.CCL11 -488 (n = 162 trio families)
|
|
A.C
|
0.62
|
69.2
|
93.1
|
3.50
|
0.06
|
|
T.C
|
0.18
|
60.8
|
39.9
|
4.32
|
0.04
|
|
(b) Independent cohort (n = 169 trio families)CCL2 -2138.CCL11 -488
|
|
A.C
|
0.63
|
75.1
|
86.0
|
0.74
|
0.4
|
|
T.C
|
0.20
|
59.9
|
52.0
|
0.56
|
0.5
|
|
(c) Combined dataset (n = 331 trio families) CCL2 -2138.CCL11 -488
|
|
A.C
|
0.62
|
144.4
|
179.1
|
3.73
|
0.05
|
|
T.C
|
0.19
|
120.6
|
91.9
|
3.89
|
0.05
|
