Table 4 Haplotype TDT of CC chemokine gene cluster SNPs.
Haplotype | Frequency | Transmitted | Non-transmitted | χ2(1df) | P (uncorrected) |
|---|---|---|---|---|---|
(a) Local cohort | |||||
5' haplotype block | |||||
4-marker haplotypes | |||||
CCL2 -2581.CCL2 -2138.CCL11 -488.CCL11 67 (n = 162 trio families) | |||||
A.A.C.G | 0.33 | 57.0 | 85.0 | 5.50 | 0.02 |
A.T.C.G | 0.18 | 61.0 | 40.0 | 4.36 | 0.04 |
3-marker haplotypes | |||||
CCL2 -2581.CCL2 -2138.CCL11 -488 (n = 162 trio families) | |||||
A.A.C | 0.33 | 56.0 | 86.0 | 6.33 | 0.01 |
A.T.C | 0.18 | 61.0 | 40.0 | 4.36 | 0.04 |
CCL2 -2138.CCL11 -488.CCL11 67 (n = 162 trio families) | |||||
A.C.G | 0.63 | 70.1 | 92.0 | 2.96 | 0.09 |
T.C.G | 0.18 | 60.9 | 40.0 | 4.34 | 0.04 |
2-marker haplotypes | |||||
CCL2 -2581.CCL2 -2138 (n = 204 trio families) | |||||
A.A | 0.52 | 89.1 | 117.1 | 3.80 | 0.05 |
CCL2 -2138.CCL11 -488 (n = 162 trio families) | |||||
A.C | 0.62 | 69.2 | 93.1 | 3.50 | 0.06 |
T.C | 0.18 | 60.8 | 39.9 | 4.32 | 0.04 |
(b) Independent cohort (n = 169 trio families)CCL2 -2138.CCL11 -488 | |||||
A.C | 0.63 | 75.1 | 86.0 | 0.74 | 0.4 |
T.C | 0.20 | 59.9 | 52.0 | 0.56 | 0.5 |
(c) Combined dataset (n = 331 trio families) CCL2 -2138.CCL11 -488 | |||||
A.C | 0.62 | 144.4 | 179.1 | 3.73 | 0.05 |
T.C | 0.19 | 120.6 | 91.9 | 3.89 | 0.05 |