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Table 3 Single locus TDT analysis of individually genotyped CC chemokine gene markers.

From: An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians

Locus All families HLA-DRB1*1501
positive
HLA-DRB1*1501
negative
RR-MS SP-MS Male Female
  T:N P T:N P T:N P T:N P T:N P T:N P T:N P
*CCL2 -2581A>G 79:89 0.4 48:57 0.4 31:32 0.9 51:68 0.1 21:16 0.4 16:13 0.60 63:76 0.3
*CCL2 -2138A>T 56:75 0.1 35:41 0.5 21:34 0.08 41:56 0.1 12:15 0.6 13:13 1 43:62 0.06
CCL11 -488C>A 88:96 0.6 45:59 0.2 43:37 0.5 68:69 0.9 15:17 0.7 20:22 0.8 68:74 0.6
*CCL11 67G>A 71:65 0.6 39:37 0.8 32:28 0.6 54:46 0.4 14:13 0.8 15:15 1 56:50 0.6
CCL8 -572C>T 143:127 0.3 84:78 0.6 59:49 0.3 107:96 0.4 23:22 0.9 28:32 0.6 115:95 0.2
*CCL5 -471C>T 64:70 0.6 45:35 0.3 19:35 0.03 47:50 0.8 14:13 0.9 14:18 0.5 50:52 0.8
CCL16 -595C>A 103:91 0.4 58:53 0.6 45:38 0.4 76:66 0.4 14:19 0.4 19:19 1 84:72 0.3
CCL14 -649T>A 100:88 0.4 64:49 0.2 36:39 0.7 81:56 0.03 9:22 0.02 17:21 0.5 83:67 0.2
*CCL15 136+88C>T 18:10 0.1 11:6 0.2 7:4 0.4 15:6 0.05 2:3 0.7 2:3 0.7 16:7 0.06
*CCL15 -1284A>C 29:27 0.8 21:20 0.9 8:7 0.8 25:17 0.2 2:5 0.3 3:6 0.3 26:21 0.5
CCL23 316T>C 85:90 0.7 54:57 0.8 31:33 0.8 70:58 0.3 8:21 0.02 13:22 0.1 72:68 0.7
*CCL23 -289A>C 62:71 0.4 42:42 1 20:29 0.2 51:46 0.6 9:17 0.1 8:19 0.03 54:52 0.9
  1. T:N = Transmitted:Non-transmitted for major allele
  2. *Markers genotyped using SNaPshot in 204 trio families; HLA-DRB1*1501 positive: 123 trio families; HLA-DRB1*1501 negative: 81 trio families; RR-MS: 147 trio families; SP-MS: 42 trio families; Male: 38 trio families; Female: 166 trio families Remaining markers genotyped using SNPlex™; All families: 269–296 trio families; HLA-DRB1*1501 positive: 156–176 trio families; HLA-DRB1*1501 negative: 113–120 trio families; RR-MS: 193–218 trio families; SP-MS: 52–56 trio families; Male: 53–60 trio families; Female: 216–236 trio families. Significant P values in bold. P values are not corrected for multiple comparisons.