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Table 1 Summary of SNPs identified by sequencing of CC chemokine genes in DNA pools that were selected for individual genotyping. Other detected SNPs are described in Supplementary Table 2.

From: An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians

   Estimated minor allele frequency Estimated relative risk
(for minor allele frequency >0.15)
Locus rsID Control pool HLA-DRB1*1501
positive pool
HLA-DRB1*1501
negative pool
Familial pool
CCL2      
   -2581A>G 1024611 0.5 0.9 0.8 0.7
   -2138A>T 1024610 0.3 1.2 1.5 1.5
CCL11      
   -488C>A 17735961 0.2 1.2 1.2 1.3
   67G>A (A>T) + 3744508 0.1 - - -
CCL8      
   -572C>T 3138035 0.3 1.1 1.0 1.2
   † 205A>C (K>Q)+ 3138038 0.2 0.8 0.8 0.7
CCL5 (-)      
   -471C>T 2107538 0.2 1.2 1.3 1.1
CCL16 (-)      
   -595C>A 854680 0.1 - - -
CCL14 (-)      
   -649T>A 854682 0.2* 1.1* 1.0* 1.4*
CCL15 (-)      
   -1284A>C 854628 <0.1 - Undetectable -
   136+88C>T Novel 0.3 0.8 0.6 0.5
CCL23 (-)      
   -289A>C 854655 0.2* 0.7* 0.5* 1.0*
   316T>C (M>V)+ 1003645 0.2* 1.0* 0.7* 1.0*
  1. All SNPs classified relative to translation start site. Relative risks determined relative to control pool. SNPs in bold were individually genotyped in second stage
  2. (-) Gene encoded in anti-sense direction; SNPs reclassified to account for this
  3. + Coding change in brackets
  4. The CCL8 205 SNP was originally selected for genotyping by SNPLEX™, but failed the SNPLEX™ algorithm, and was replaced with the CCL8 -572 SNP
  5. * Heterozygous individual correction applied
  6. rsID: SNP identification number