Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects

Table 6 Haplotype Analysis of Betacellulin Coding Variants

Combination	Haplotype	Case Frequency	Control Frequency
C7G/L44F/L124M	TCT	0.334	0.355
	TCA	0.163	0.151
	GCT	0.290	0.271
	GCA	0.129	0.118
	GTT	0.062	0.075
C7G/L44F	TC	0.490	0.500
	TT	0.026	0.031
	GC	0.426	0.395
	GT	0.057	0.073
L44F/L124M	CT	0.624	0.627
	CA	0.292	0.268
	TT	0.081	0.098
C7G/L124M	TT	0.354	0.380
	TA	0.161	0.151
	GT	0.352	0.346
	GA	0.132	0.123

Predicted haplotypes and frequencies in cases and controls are shown from the Phase 2.1 program. Similar results were obtained from HaploView 3.2. Haplotypes with a predicted frequency of over 5% are shown, with the nucleotides as reported in Table 3. No differences approached significance.

ISSN: 1471-2350