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Table 1 NAT2 genotypes in controls and colon cancer patients

From: N-acetyltransferase 2 (NAT2) gene polymorphisms in colon and lung cancer patients

Genotypes Deduced phenotypes Controls Colon cancer Total Odds ratios (95% confidence interval)2
c.481 C>T c.590 G>A c.857 G>A   n = 243 n = 92 n = 335  
CC GG GG rapid 5.4% (13) 9.8% (9) 6.6% (22) reference
CT    rapid 23.0% (56) 18.5% (17) 21.8% (73) 0.44 (0.16–1.20)
  GA   rapid 8.6% (21) 13.0% (12) 9.9% (33) 0.83 (0.27–2.49)
   GA rapid 0.4% (1) 2.2% (2) 0.9% (3) 2.89 (0.23–36.87)
TT    slow1 22.2% (54) 13.0% (12) 19.7% (66) 0.32 (0.11–0.92)**
  AA   slow 9.5% (23) 13.0% (12) 10.4% (35) 0.75 (0.25–2.26)
   AA slow 0 0 0  
  AA GA slow 4.1% (10) 0 3.0% (10)  
CT GA   slow 23.9% (58) 29.3% (27) 25.4% (85) 0.67 (0.26–1.77)
CT   GA slow 2.5% (6) 1.0% (1) 2.1% (7) 0.24 (0.03–2.36)
  GA GA slow 0.4% (1) 0 0.3% (1)  
  1. 1 c.481C>T is a silent mutation associated also with NAT*12C (c.481C>T, c.803A>G) which is a rapid allele (see Hein et al. 2000, [1])
  2. 2 For the calculation of ORs for individual genotypes, NAT2*4/*4 [c. 481CC + c.590 GG + c.857 GG] was used as reference and all corresponding odds ratios were determined with respect to this reference.
  3. ** significant.