Skip to main content

Table 5 Relationship between β3-Adrenergic Receptor genotypes and fracture risk

From: β3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)

 

Any fracture

Hip fracture

Vertebral fracture

Wrist/forearmb

Women

    

ADRB3 unadjusteda

0.74 (0.42, 1.31)

0.66 (0.23,1.92)

0.56 (0.21, 1.46)

0.55 (0.21, 1.43)

Adjusted for age (1)

0.72 (0.40, 1.28)

0.66 (0.22,1.96)

0.55 (0.21, 1.43)

0.54 (0.21, 1.42)

Adjusted for FNBMD (2)

0.84 (0.46, 1.55)

0.83 (0.25, 2.77)

0.62 (0.24, 1.64)

0.61 (0.23, 1.61)

Adjusted for BMI (3)

0.76 (0.42, 1.37)

0.82 (0.27, 2.44)

0.60 (0.23, 1.56)

0.57 (0.22, 1.50)

Adjusted for (1) and (2)

0.84 (0.45, 1.55)

0.78 (0.23, 2.61)

0.60 (0.23, 1.58)

0.61 (0.23, 1.60)

Adjusted for (1) and (3)

0.74 (0.41, 1.33)

0.70 (0.23, 2.16)

0.57 (0.22, 1.51)

0.56 (0.22, 1.48)

Adjusted for (1) and (2) and (3)

0.83 (0.45, 1.53)

0.75 (0.22, 2.56)

0.60 (0.23, 1.59)

0.61 (0.23, 1.60)

Men

    

ADRB3 unadjusteda

1.29 (0.57, 2.92)

1.39 (0.28, 6.76)

1.69 (0.59, 4.88)

1.84 0.19, 18.18)

Adjusted for age (1)

1.57 (0.68, 3.65)

2.87 (0.50, 16.39)

2.03 (0.69, 6.02)

-

Adjusted for FNBMD (2)

1.25 (0.52, 3.04)

1.47 (0.29, 7.46)

1.88 (0.62, 5.71)

-

Adjusted for BMI (3)

1.28 (0.56, 2.89)

1.34 (0.27, 6.58)

1.66 (0.57, 4.78)

-

Adjusted for (1) and (2)

1.47 (0.60, 3.62)

3.03 (0.52, 17.54)

2.15 (0.69, 6.67)

-

Adjusted for (1) and (3)

1.57 (0.67, 3.65)

2.85 (0.50, 16.39)

2.02 (0.68, 6.02)

-

Adjusted for (1) and (2) and (3)

1.46 (0.59, 3.62)

2.88 (0.48, 7.24)

2.15 (0.69, 6.67)

-

  1. Values are Odds ratio and 95% CI;
  2. a Arg-allele carriers were considered the risk factor in the model and Trp/Trp genotype was the reference group.
  3. badjusted OR was not calculated for wrist/forearm fracture in men due to small number of fracture.