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Table 2 Mean and difference (95% CI) in body mass index (kg/m2) between individuals homozygous and heterozygous carriers of the 363S allele of the GRL gene and homozygotes for the N363 allele in studies with two population group

From: Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity

 

Normal weight subjects

Obese subjects

Study

N363/363S 363S/363S

N363/N363

Mean difference

95% CI

% carriers

N363/363S 363S/363S

N363/N363

Mean difference

95% CI

% carriers

 

n

Mean BMI

n

Mean BMI

    

n

Mean BMI

n

Mean BMI

    

Published data

                

Lin et al. 1999

27

26.5

171

25.7

0.8

-0.9

2.5

13.64

39

43.6

107

42.9

0.7

-2.5

3.8

26.71

Lin et al. 2003

33

26.6

230

25.6

1.0

-0.5

2.5

12.55

39

43.5

111

43.1

0.4

-2.7

3.5

26.00

Echwald et al. 2001

79

26.4

775

26.1

0.2

-0.6

1.1

9.25

66

35.9

675

35.7

0.2

-1.2

1.7

8.91

Total (n)

139

 

1176

     

144

 

893

     

Novel data

                

Spain (Navarra)

                

Adults

7

22.4

147

22.3

0.1

-1.3

1.4

4.54

2

37.1

157

37.6

-0.5

-8.5

7.5

1.26

Children

8

18.6

177

18.9

-0.3

-2.2

1.6

4.32

4

24.3

181

27.6

-3.3

-7.9

1.3

2.16

Germany

                

Children and adolescents

22

17.6

234

18.3

-0.7

-1.2

-0.2

8.59

8

41.3

170

35.4

5.9

1.7

10.2

4.49

Total (n)

37

 

558

     

14

 

508

     
  1. In the study by Echwald et al (2001) only men were recruited from Copenhagen, Denmark, mean age = 45. The study by Lin et al (1999) included men (53%) and women (47%), mean age = 50, from Sydney (Australia), the study by Lin et al (2003) included men (80%) and women (20%), mean age = 45, from Sydney (Australia). The Navarra adults study enrolled men (20%) and women (80%), mean age = 40, from Navarra (North of Spain). The Navarra children study encompassed boys (53%) and girls (53%), mean age = 11 from Navarra (North of Spain). The German children study consisted of boys (50%) and girls (50%), mean age = 14 from West and South of Germany.