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Figure 1 | BMC Medical Genetics

Figure 1

From: Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue

Figure 1

Pedigree showing HNPCC family. An arrow indicates the male index patient (III:3) diagnosed with colorectal adenocarcinoma at the age of 23 years. Family members suffering from a malignancy are indicated by a shaded circle or square. The age, type of malignancy, as well as the generation (roman figures), are described below the indicated patient. The family fulfill the Amsterdam-I criteria with presence of extracolonic tumors in the extended pedigree, having more than three carcinomas of colon (C) or ovary (O) in the affected members. The syndrome is present in all three generations (I-III) and three family members are younger than 50 years (III:3, II:1 and I:3). At the moment of the study the proband's mother (II-5) was an unaffected carrier, but two years later she developed an endometrial (E) adenocarcinoma.

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BMC Medical Genetics

ISSN: 1471-2350

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