Table 2 Allele and genotype frequencies of RANTES, IL-8, MCP-1 and IL-1α polymorphisms in SLE patients and healthy controls.
SLE patients | Controls | P | OR (95%CI) | |||
|---|---|---|---|---|---|---|
RANTES -403 | n | % | n | % | ||
Genotypes | ||||||
GG | 369 | 73.8 | 333 | 69.3 | 0.1 | |
GA | 113 | 22.6 | 135 | 28 | 0.04 | 0.75 (0.55–1.01) |
AA | 18 | 3.6 | 13 | 2.7 | 0.4 | |
Alleles | ||||||
G | 851 | 85 | 801 | 83.3 | ||
A | 149 | 15 | 161 | 16.7 | 0.2 | |
RANTES R3 | n | % | n | % | ||
Genotypes | ||||||
CC | 326 | 73.8 | 340 | 77.6 | 0.06 | |
CT | 104 | 23.5 | 90 | 20.6 | 0.3 | |
TT | 12 | 2.7 | 8 | 1.8 | 0.4 | |
Alleles | ||||||
C | 756 | 85.5 | 770 | 88 | ||
T | 128 | 14.5 | 106 | 12 | 0.1 | |
IL-8 -353 | n | % | n | % | ||
Genoypes | ||||||
AA | 126 | 28.7 | 125 | 30.3 | 0.6 | |
AT | 215 | 49 | 194 | 47.1 | 0.5 | |
TT | 98 | 22.3 | 93 | 22.6 | 0.9 | |
Alleles | ||||||
A | 467 | 53.2 | 444 | 53.8 | ||
T | 411 | 46.8 | 380 | 46.2 | 0.7 | |
IL-8 +781 | n | % | n | % | ||
Genotypes | ||||||
CC | 164 | 35 | 143 | 33.3 | 0.6 | |
CT | 238 | 51 | 221 | 51.5 | 0.8 | |
TT | 65 | 14 | 65 | 15.2 | 0.6 | |
Alleles | ||||||
C | 566 | 60.6 | 507 | 59.1 | ||
T | 368 | 39.4 | 351 | 40.9 | 0.5 | |
IL-1α -889 | n | % | n | % | ||
Genotypes | ||||||
CC | 220 | 52.7 | 209 | 49.7 | 0.4 | |
CT | 164 | 39.3 | 166 | 39.5 | 0.9 | |
TT | 33 | 7.9 | 45 | 10.7 | 0.2 | |
Alleles | ||||||
C | 604 | 72.4 | 584 | 69.5 | ||
T | 230 | 27.6 | 256 | 30.5 | 0.2 | |
MCP-1 -2518 | n | % | n | % | ||
Genotypes | ||||||
AA | 238 | 57.2 | 250 | 58.5 | 0.6 | |
AG | 173 | 35 | 154 | 36 | 0.7 | |
GG | 39 | 7.8 | 23 | 5.4 | 0.1 | |
Alleles | ||||||
A | 739 | 74.6 | 654 | 76.6 | ||
G | 251 | 25.4 | 200 | 23.4 | 0.3 | |