Analysis of common PTPN1gene variants in type 2 diabetes, obesity and associated phenotypes in the French population

Table 6 Association analysis with quantitative traits related to the lipid and arterial blood pressure profiles

			HDL*		LDL		Triglycerides		Systolic pressure*		Diastolic pressure*
SNPs	Genotypes	N	Mean	pdom prec	Mean	pdom prec	Mean	pdom prec	Mean	pdom prec	Mean	pdom prec
rs2426157	AA	367	1.75 ± 0.44	0.12	3.65 ± 0.84	0.05	0.97 ± 0.51	0.68	131.3 ± 13.0	0.03	78.1 ± 8.4	0.87
	AG	289	1.77 ± 0.45	0.29	3.55 ± 0.80	0.52	0.98 ± 0.50	0.27	129.2 ± 12.5	0.04	77.9 ± 8.7	0.02
	GG	65	1.77 ± 0.40		3.55 ± 0.84		0.94 ± 0.51		133.6 ± 10.5		80.8 ± 7.2
rs941798	AA	223	1.78 ± 0.42	0.06	3.54 ± 0.86	0.13	0.94 ± 0.47	0.09	130.8 ± 12.1	0.89	78.7 ± 7.8	0.53
	AG	345	1.75 ± 0.46	0.05	3.61 ± 0.80	0.17	0.97 ± 0.48	0.03	130.4 ± 13.2	0.20	78.2 ± 8.9	0.87
	GG	152	1.71 ± 0.41		3.69 ± 0.83		1.05 ± 0.60		131.6 ± 12.7		78.1 ± 8.9
rs2426159	AA	201	1.72 ± 0.43	0.03	3.71 ± 0.84	0.03	1.04 ± 0.58	0.02	132.4 ± 14.2	0.03	78.6 ± 8.9	0.36
	AG	360	1.77 ± 0.45	0.65	3.58 ± 0.81	0.20	0.95 ± 0.47	0.38	130.1 ± 12.2	0.98	78 ± 8.7	0.82
	GG	161	1.77 ± 0.44		3.51 ± 0.83		0.94 ± 0.48		129.9 ± 11.2		78.4 ± 7.4
rs6020608	CC	366	1.74 ± 0.44	0.18	3.65 ± 0.84	0.08	0.97 ± 0.51	0.87	131.5 ± 13.4	0.03	78.2 ± 8.8	0.88
	CT	291	1.77 ± 0.45	0.81	3.55 ± 0.81	0.83	0.99 ± 0.50	0.61	129.2 ± 12.2	0.02	77.9 ± 8.4	0.03
	TT	64	1.72 ± 0.35		3.58 ± 0.82		0.95 ± 0.50		133.4 ± 10.8		80.7 ± 7.5

Data are means ± SD for nonadjusted variables. Variables were transformed and adjusted by covariates (age, sex, BMI). The HDL and blood pressure measures variables had non-Gaussian residuals and were analysed by non-parametric tests as indicated by an asterisk (*); other variables were analysed by an ANOVA test. Results were presented for dominant and recessive models. Only SNPs showing an association are presented here.

ISSN: 1471-2350