Figure 1

Linkage disequilibrium plot of the PTPN1 gene region evaluated in a group of 736 French normoglycaemic non-obese subjects The PTPN1 gene is shown by the black line with boxes representing its 10 exons. The localisation of the selected SNPs is indicated by the dotted line. The linkage disequilibrium plot represents the pairwise LD (D') estimated from the control group (C2) using the four gamete rule implemented in the Haploview software. The values indicated in each square is the D' value, when no value is indicated D' = 1. The red colour indicates strong (D'> 0.8) and statistically significant (LOD>2) LD. Above the gene, the haplotype combinations are indicated with their respective frequencies; they were determined using the Haploview and Strategy softwares.