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Table 4 Haplotypes of A>G (-6) – Thr174Met – Met235Thr SNPs in AGT gene tested for association with diabetic chronic renal insufficiency.

From: Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms

Haplotype*

DM

CRI

χ2

P (df = 2)

O.R. (95%CI)

 

n

Freq.

n

Freq.

   

A-C-T

92

0.236

23

0.06

47.38

0.0000**

0.260 (1.27–0.33)

A-C-C

93

0.24

174

0.45

16.99

0.0000**

1.93 (1.41–2.65)

A-T-T

08

0.20

01

0.003

5.4

0.02

0.125 (0.015–1.00)

A-T-C

16

0.04

30

0.08

4.76

0.029

1.98 (1.06–3.69)

G-C-T

144

0.37

118

0.31

3.32

0.068

0.758 (0.56–1.02)

G-C-C

25

0.06

25

0.065

0.06

0.81

0.93 (0.52–1.67)

G-T-T

06

0.015

01

0.003

3.526

0.06

0.167 (0.02–1.39)

G-T-C

06

0.015

14

0.036

3.14

0.076

2.34 (0.89–6.15)

  1. * Order of SNPs in AGT haplotypes: A>G (-6) – Thr174Met – Met235Thr
  2. ** Significant after Bonferroni correction α = 0.006