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Table 1 Genotype frequencies for the polymorphisms at the MMP9 locus in the study population and risk estimates from CLR analysis of matched case-control pairs.

From: A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatisinfection

Polymorphisms at the MMP9 locus in the study population

Genotype

# of genotype (freq)

crude M-H OR(95%CI)

CLR-OR (95%CI)

P value

 

Scarring cases (TS)

controls

   

Q279R AA

330(0.55)

311(0.48)

1.18 (1.00, 1.38)

reference

-

Q279R AG

209(0.35)

270(0.42)

0.80 (0.67, 0.96)

0.70(0.54, 0.89)

0.004

Q279R GG

62(0.10)

61(0.10)

1.07 (0.74, 1.55)

0.95(0.64,1.41)

0.805

R574P CC

450(0.73)

459(0.72)

0.98 (0.86, 1.12)

reference

-

R574P CG

155(0.25)

161(0.25)

0.96 (0.77, 1.20)

0.97(0.74, 1.28)

0.845

R574P GG

15(0.02)

14(0.02)

1.07 (0.52, 2.22)

1.07(0.50, 2.28)

0.857

G607G AA

204(0.35)

193(0.35)

1.06 (0.87, 1.29)

reference

-

G607G AC

265(0.46)

268(0.48)

0.99 (0.83, 1.17)

0.91(0.68, 1.22)

0.538

G607G CC

114(0.20)

94(0.17)

1.21 (0.92, 1.59)

1.06(0.73, 1.55)

0.746

V694V GA

453(0.75)

443(0.74)

1.02 (0.90, 1.17)

reference

-

V694V GG

138(0.23)

145(0.24)

0.95 (0.75, 1.20)

0.94(0.71, 1.26)

0.694

V694V AA

14(0.02)

11(0.02)

1.27 (0.58, 2.80)

1.11 (0.49, 2.48)

0.807

Risk estimates from CLR analysis of matched case-control pairs

Q279R AA

166(0.61)

131(0.48)

1.28 (1.01, 1.59)

reference

-

Q279R AG

75(0.28)

117(0.43)

0.64 (0.48, 0.86)

0.57 (0.38, 0.85)

0.006

Q279R GG

30(0.11)

25(0.11)

1.20 (0.71, 2.04)

0.95 (0.54, 1.69)

0.945

R574P CC

218(0.74)

213(0.71)

1.02 (0.85, 1.24)

reference

-

R574P CG

68(0.23)

80(0.27)

0.85 (0.62, 1.17)

0.76(0.50, 1.14)

0.181

R574P GG

7(0.02)

7(0.02)

1.00 (0.35, 2.85)

1.06(0.31–3.69)

0.927

G607G AA

97(0.35)

101(0.37)

0.96 (0.73, 1.27)

reference

-

G607G AC

127(0.46)

132(0.48)

0.96 (0.75, 1.23)

0.96(0.63, 1.46)

0.851

G607G CC

55(0.20)

43(0.16)

1.28 (0.86, 1.91)

1.03(0.60, 1.78)

0.908

V694V GA

225(0.79)

213(0.76)

1.06 (0.88, 1.27)

reference

-

V694V GG

54(0.19)

63(0.22)

0.86 (0.60, 1.23)

0.94(0.60, 1.48)

0.371

V694V AA

5(0.02)

5(0.02)

1.00 (0.29, 3.45)

0.79 (0.21, 2.95)

0.725