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Table 2 Crude odds ratio for all CAD risk factors among CAD and CON groups

From: T null and M nullgenotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking

Risk factor

Status

CAD

CON

Odds ratio

[95% C.I]

pvalue

Genotype (haplotype)

Twild M wild

311

627

Reference

-

-

T1 and M1 genes

Twild Mnull

280

69

8.17

6.01 – 11.1

< .001

 

Tnull Mwild

88

18

9.84

5.68 – 17.2

< .001

 

Tnull Mnull

375

48

15.7

11.2 – 22.2

< .001

Genotype (T1 gene)

T wild

591

696

Reference

-

-

 

T null

463

66

8.26

6.19 – 11.05

< .001

Genotype (M1 gene)

M wild

399

645

Reference

-

-

 

M null

655

117

9.05

7.12 – 11.5

< .001

Smoking

No

630

648

Reference

-

-

 

Yes

424

114

3.83

3.01 – 4.87

< .001

Age

< 40

172

165

Reference

-

-

 

≥ g40

882

597

1.42

1.11 – 1.81

.004

Hypercholesterolemia

No

369

455

Reference

-

-

 

Yes

685

307

2.71

2.27 – 3.34

< .001

Hypertriglyceridemia

No

438

479

Reference

-

-

 

Yes

616

283

2.38

1.97 – 2.89

< .001

DM

No

462

461

Reference

-

-

 

Yes

592

301

1.96

1.62 – 2.37

< .001

FH

No

764

600

Reference

-

-

 

Yes

290

162

1.40

1.13 – 1.75

.002

Gender

F

412

298

Reference

-

-

 

M

642

464

1.0

0.82 – 1.22

.1

Hypertension

No

89

265

Reference

-

-

 

Yes

965

497

5.77

4.41 – 7.59

< .001

Obesity

No

331

417

Reference

-

-

 

Yes

723

345

2.64

2.17 – 3.22

< .001

MI

No

951

707

Reference

-

-

 

Yes

103

55

1.39

0.98 – 1.99

.067