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Table 3 Characteristics of studies on NAT2 polymorphisms and Parkinson's disease: patients and control subjects

From: N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease

Authors, country Ethnicity of participants PD Control
   Source Type of PD cases N Male sex % Age at onset (yr) Diagnostic criteria Source N Age at exam (yr) Male sex %
Van der Walt et al. 2003, USA NG1 DCHG Morris Udall PD Cntr., DCHG/Glaxo-Smith Kline PD Genetics Collaboration familial 397 families 607 affected indvls. 59 62 ± 13 EOPD: ≤ 40 LOPD:> 40 AAE: 67 ± 12 levodopa therapy, absence of parkin mutations healthy members of affected families 872 indvls. 67 ± 12 45
Bandmann et al. 1997, 2000, UK Caucasian UK PD Brain Bank, Inst. Psychiatry, London familial, sporadic 100 familial 100 sporadic 55 familial 65 sporadic 68.4 ± 7.7 (51–85) age at death (sporadic): 76.7 ± 7.9 (51–94) criteria, Maraganore et al. 19912 UK PD Brain Bank, normal brains 100 77.1 ± 8.8 (60–90) 65
Nicholl et al. 1999, UK Caucasian West Midlands Region, UK familial, sporadic 30 familial 176 sporadic 57 familial 60 sporadic 63.9 familial 64.5 sporadic response to levodopa or dopamine agonists, = 2 cardinal PD features hospitals in two separate regions within the UK West Midlands 30 familial 176 sporadic 63.9 familial 63 sporadic 57 familial 60 sporadic
Chaudhary et al. 2005, India Indian two hospitals: New Delhi, Bangalore sporadic 267 74 EOPD: 69 LOPD: 79 31.8 ± 8.5 EOPD : ≤ 40 52.35 ± 9.0 LOPD:> 40 criteria, UK PD Brain Bank healthy spouses of PD subjects, outpatient dept participating hospitals 324 45.83 ± 2.88 EOPD control 64.04 ± 8.13 LOPD control 75 EOPD control 74 LOPD control
Chan et al. 2003, China Hongkong Chinese two hospitals, Hongkong sporadic 99 60 71.7 (46–93) 4 patients ≤ 45 criteria, Maraganore et al. 19912, levodopa therapy same hospitals as PD cases 126 70.2 (39–96) 50
Bialecka et al. 2002, Poland Caucasian Pomeranian region sporadic 54 NG1 68 = 2 cardinal PD features same region, randomly selected 85 73.4 ± 5.8(65–87) NG1
Maraganore et al. 2000, USA Caucasian (almost) Mayo Clinic referrals (from MN, WI, ND, SD) and PD study Olmsted County, MN sporadic 139 65 62 (31–82) AAE: 69 (39–91) = 2 cardinal PD features, levodopa therapy Olmsted County, MN, healthy spouses of PD subjects 113 72 (37–90) 35
Dupret et al. 1999, France Caucasian hospitals and clinics in Champagne-Ardenne sporadic 68 67 61 ± 9 (25–88) AAE: 71 ± 9 cardinal PD features same region as PD cases 211 43.8 ± 6.1 50
Harhangi et al. 1999, Netherlands Caucasian PD cases in Rotterdam sporadic 80 34 77.3 ± 8.3 (57–99) = 2 cardinal PD features same region as PD cases 161 78 ± 8.3 (57–98) 39
Agundez et al. 1998, Spain Caucasian hospitals in Madrid and vicinity sporadic 121 EOPD: 54 LOPD: 52 41.3 ± 6.4 (28–50) OEPD: 28–50 67.3 ± 8.2 (51–83) LOPD : >51 criteria, Hughes et al. 19923 volunteers from the same region 121 34.2 ± 12.5 53
  1. 1NG =not given
  2. 2Maraganore DM, Harding AE, Marsden CD. A clinical and genetic study of familial Parkinson's disease. Mov Disord 1991; 6:205-211.
  3. 3Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55:181-184.