Table 3 Characteristics of studies on NAT2 polymorphisms and Parkinson's disease: patients and control subjects
From: N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease
Authors, country | Ethnicity of participants | PD | Control | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Source | Type of PD cases | N | Male sex % | Age at onset (yr) | Diagnostic criteria | Source | N | Age at exam (yr) | Male sex % | ||
Van der Walt et al. 2003, USA | NG1 | DCHG Morris Udall PD Cntr., DCHG/Glaxo-Smith Kline PD Genetics Collaboration | familial | 397 families 607 affected indvls. | 59 | 62 ± 13 EOPD: ≤ 40 LOPD:> 40 AAE: 67 ± 12 | levodopa therapy, absence of parkin mutations | healthy members of affected families | 872 indvls. | 67 ± 12 | 45 |
Bandmann et al. 1997, 2000, UK | Caucasian | UK PD Brain Bank, Inst. Psychiatry, London | familial, sporadic | 100 familial 100 sporadic | 55 familial 65 sporadic | 68.4 ± 7.7 (51–85) age at death (sporadic): 76.7 ± 7.9 (51–94) | criteria, Maraganore et al. 19912 | UK PD Brain Bank, normal brains | 100 | 77.1 ± 8.8 (60–90) | 65 |
Nicholl et al. 1999, UK | Caucasian | West Midlands Region, UK | familial, sporadic | 30 familial 176 sporadic | 57 familial 60 sporadic | 63.9 familial 64.5 sporadic | response to levodopa or dopamine agonists, = 2 cardinal PD features | hospitals in two separate regions within the UK West Midlands | 30 familial 176 sporadic | 63.9 familial 63 sporadic | 57 familial 60 sporadic |
Chaudhary et al. 2005, India | Indian | two hospitals: New Delhi, Bangalore | sporadic | 267 | 74 EOPD: 69 LOPD: 79 | 31.8 ± 8.5 EOPD : ≤ 40 52.35 ± 9.0 LOPD:> 40 | criteria, UK PD Brain Bank | healthy spouses of PD subjects, outpatient dept participating hospitals | 324 | 45.83 ± 2.88 EOPD control 64.04 ± 8.13 LOPD control | 75 EOPD control 74 LOPD control |
Chan et al. 2003, China | Hongkong Chinese | two hospitals, Hongkong | sporadic | 99 | 60 | 71.7 (46–93) 4 patients ≤ 45 | criteria, Maraganore et al. 19912, levodopa therapy | same hospitals as PD cases | 126 | 70.2 (39–96) | 50 |
Bialecka et al. 2002, Poland | Caucasian | Pomeranian region | sporadic | 54 | NG1 | 68 | = 2 cardinal PD features | same region, randomly selected | 85 | 73.4 ± 5.8(65–87) | NG1 |
Maraganore et al. 2000, USA | Caucasian (almost) | Mayo Clinic referrals (from MN, WI, ND, SD) and PD study Olmsted County, MN | sporadic | 139 | 65 | 62 (31–82) AAE: 69 (39–91) | = 2 cardinal PD features, levodopa therapy | Olmsted County, MN, healthy spouses of PD subjects | 113 | 72 (37–90) | 35 |
Dupret et al. 1999, France | Caucasian | hospitals and clinics in Champagne-Ardenne | sporadic | 68 | 67 | 61 ± 9 (25–88) AAE: 71 ± 9 | cardinal PD features | same region as PD cases | 211 | 43.8 ± 6.1 | 50 |
Harhangi et al. 1999, Netherlands | Caucasian | PD cases in Rotterdam | sporadic | 80 | 34 | 77.3 ± 8.3 (57–99) | = 2 cardinal PD features | same region as PD cases | 161 | 78 ± 8.3 (57–98) | 39 |
Agundez et al. 1998, Spain | Caucasian | hospitals in Madrid and vicinity | sporadic | 121 | EOPD: 54 LOPD: 52 | 41.3 ± 6.4 (28–50) OEPD: 28–50 67.3 ± 8.2 (51–83) LOPD : >51 | criteria, Hughes et al. 19923 | volunteers from the same region | 121 | 34.2 ± 12.5 | 53 |