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Table 2 NAT2 genotypes in controls and patients with Parkinson's disease

From: N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease

Genotypes Deduced phenotypes Controls Parkinson's disease Odds ratios (95% confidence interval) χ2
c.481 C>T c.590 G>A c.857 G>A   n = 243 95% CI n = 124 95% CI   
CC GG GG rapid 5.4 % (13) 2.9 – 9.0 9.7 % (12) 5.1 – 16.3 1.90 (0.85–4.25) NS
CT    rapid 23.0 % (56) 17.9–28.9 25.0 % (31) 17.7 – 33.6 1.11 (0.67–1.84) NS
  GA   rapid 8.6 % (21) 5.4 – 12.9 15.3 % (19) 9.5 – 22.9 1.91 (0.99–3.68) p < 0.01
   GA rapid 0.4 % (1) 0.01 – 2.3 ND 0.0 – 2.9 0.000* NS
TT    slow1 22.2 % (54) 17.2 – 28.0 20.2 % (25) 13.5 – 28.3 0.88 (0.52–1.51) NS
  AA   slow 9.5 % (23) 6.1 – 13.9 5.7 % (7) 2.3 – 11.3 0.57 (0.24–1.36) NS
  AA GA slow 4.1 % (10) 2.0 – 7.4 3.2 % (4) 0.9 – 8.1 0.78 (0.24–2.53) NS
CT GA   slow 23.9 % (58) 18.7 – 29.7 17.0 % (21) 10.8 – 24.7 0.65 (0.37–1.13) NS
CT   GA slow 2.5 % (6) 0.9 – 5.3 2.4 % (3) 0.5 – 6.9 0.98 (0.24–3.99) NS
  GA GA slow 0.4 % (1) 0.01 – 2.3 0.8 % (1) 0.02 – 4.4 1.97 (0.13–30.24) NS
   AA slow ND 0.0 – 1.5 0.8 % (1) 0.02 – 4.4 * NS
  1. *The confidence intervals for the percentages were computed according to Pearson-Clopper, whereas confidence intervals for the odds ratios were computed assuming asymptotic log normality. To avoid undefined results, some estimates were not computed.
  2. 1c.481 C>T is a silent mutation associated also with NAT2*12C (c.481 C>T, c.803A>G) and which is a rapid allele (see Hein et al. [7] )