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Table 1 Characteristics of cultured fibroblasts.

From: Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21

Cell Line

Early Passage

Late Passage

 

Passage no.

Doubling time (d)

beta-gal % pos.

Passage no.

Doubling time (d)

beta-gal % pos.

DS1

13

2

<1

23

5.5

63.4

DS2

7

1

<1

12

19.5

37.2

DS3

4

2.5

<1

11

9

41.0

DS4

10

1.5

<1

14

8

47.5

DS5

3

5

nd

nd

nd

nd

C1

12

2

<1

24

12

55.5

C2

9

1.5

6.7

15

21

63.3

C3

5

1.5

<1

11

9.5

46.2

C4

10

2.5

<1

14

4.5

34.0

C5

3

2

n.d.

n.d.

n.d.

n.d.

C6

3

5

n.d.

n.d.

n.d.

n.d.