Haplotype analysis suggest common founders in carriers of the recurrent BRCA2mutation, 3398delAAAAG, in French Canadian hereditary breast and/ovarian cancer families

Table 2 Genotypes of an index case from 3398delAAAAG mutation carrier families.

Families reported previously [10] (*). The 3398delAAAAG associated alleles are in boldface type, haplotypes not segregating with the BRCA2 mutant alleles are in italics, and genotypes of unphased alleles are separated by a comma. Phase was established by comparing genotypes of two to nine family members per family where additional members were available for analysis^t. Alleles common in the French Canadian population reported previously [6]. The physical distance between D13S260 to D13S1695 is about 3.5 Mb [15]; BRCA2 is located between D13S1697 and D13S701 [11] The intermarker distances are D13S260 – 1.0 cM – D13S1699 – 0.7 cM – D13S1698 – 0.6 cM – D13S1697 – 0.2 cM – BRCA2 – 0.5 cM – D13S1701 – 0.6 cM – D13S171 – 0.3 cM – D13S1695 [12].

ISSN: 1471-2350