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Table 4 Association analyses in type 1 diabetes families and case-control sample sets for ADAM33 SNPs

From: Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases

Published SNP Set 1 families Cases and controls
  MAF N parent-child trios (T/NT) PTDT Allelic RR [95% CI] Genotype RR [95% CI] MAF N cases/controls P1df Allelic OR [95%CI] Genotype OR [95%CI]
ST+4 rs44707 0.39 703 (421/443) 0.02* 0.95 [0.83–1.09] C/C 1.00 [ref] A/C 0.80 [0.67–0.96] A/A 0.99 [0.76–1.30] n/a n/a n/a n/a n/a
**V4 rs2787094 0.23 653 (350/451) 0.0004 0.78 [0.67–0.89] G/G 1.00 [ref] G/C 0.78 [0.67–0.92] C/C 0.59 [0.41–0.85] 0.22 4326/4610 0.57 1.02 [0.95–1.10] G/G 1.00 [ref] G/C 1.04 [0.95–1.14] C/C 0.99 [0.81–1.22]
Q-1 rs612709 0.14 402 (219/247) 0.02* 0.89 [0.74–1.06] G/G 1.00 [ref] G/A 0.99 [0.81–1.21] A/A 0.42 [0.22–0.83] n/a n/a n/a n/a n/a
ST+7 rs574174 0.20 669 (392/393) 0.97 1.00 [0.87–1.15] T/T 1.00 [ref] T/C 1.02 [0.87–1.20] C/C 0.92 [0.63–1.34] n/a n/a n/a n/a n/a
T+1 rs2280089 0.13 512 (274/304) 0.21 0.90 [0.77–1.06] G/G 1.00 [ref] C/G 0.90 [0.75–1.07] C/C 0.83 [0.49–1.43] n/a n/a n/a n/a n/a
T2 rs2280090 0.13 520 (277/314) 0.13 0.88 [0.75–1.04] T/T 1.00 [ref] T/C 0.88 [0.73–1.05] C/C 0.81 [0.47–1.39] n/a n/a n/a n/a n/a
  1. MAF: minor allele frequency. T: transmitted. NT: not transmitted. TDT: transmission/disequilibrium test. P value. RR: relative risk. 95% CI: 95% confidence intervals. OR: odd ratios. N: number. n/a: not attempted.
  2. * Two degree of freedom GTRR (genotype relative risk) P value is reported as its significantly different to the TDT P value.
  3. ** In set 1 and 2 families (1075(571/737) parent-child trios) for ADAM33 V4, P TDT = 4.43 × 10-6, with allelic RR = 0.77 [0.69–0.86] and genotype relative risks: G/G 1.00 [ref], G/C 0.80 [0.70–0.91], C/C 0.54 [0.40–0.73].
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