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Table 3 Association analyses in type 1 diabetes families and case-control sample sets for rheumatoid arthritis, inflammatory bowl disease and multiple sclerosis associated polymorphisms.

From: Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases

Published SNP Set 1 and 2 families Cases and controls
  MAF N parent-child trios (T/NT) PTDT Allelic RR [95% CI] Genotype RR [95% CI] MAF N Cases/controls P1df Allelic OR [95%CI] Genotype OR [95%CI]
IL1RN +2017 T>C rs2419598 0.28 1418 (916/865) 0.23 1.06 [0.96–1.16] T/T 1.00 [ref] T/C 1.12 [0.99–1.25] C/C 1.03 [0.83–1.28] n/a n/a n/a n/a n/a
IL1RA -889 C>T rs1800587 0.30 1431 (925/913) 0.78 1.01 [0.92–1.11] C/C 1.00 [ref] C/T 1.02 [0.91–1.15] T/T 1.02 [0.83–1.25] n/a n/a n/a n/a n/a
CARD15           
SNP8 +2023C>T rs2066844 0.03 252 (123/143) 0.22 0.86 [0.68–1.09] C/C 1.00 [ref] C/T 0.90 [0.70–1.15] T/T 0.22 [0.03–1.66] n/a n/a n/a n/a n/a
SNP12 +3641G>C rs2066845 0.01 127 (57/72) 0.19 0.79 [0.56–1.12] G/G 1.00 [ref] G/C 0.81 [0.57–1.14] C/C - n/a n/a n/a n/a n/a
SNP13 +2936insC ss28514842 0.01 143 (73/72) 0.93 1.01 [0.73–1.40] 1/1 1.00 [ref] 1/2 1.00 [0.72–1.38] 2/2 2.99 [0.19–48.22] n/a n/a n/a n/a n/a
IGR2198 G>C rs11739135 0.40 1511 (988/1008) 0.65 0.98 [0.90–1.07] G/G 1.00 [ref] G/C 0.95 [0.84–1.07] C/C 0.98 [0.82–1.17] n/a n/a n/a n/a n/a
SLC22A4 G>A rs3792876 n/a n/a n/a n/a n/a 0.08 3303/3558 0.93 0.99 [0.87–1.14] C/C 1.0 [ref] C/T 1.01 [0.87–1.16] T/T 0.83 [0.40–1.70]
SLC22A4 C>T rs2073838 n/a n/a n/a n/a n/a 0.08 3290/3549 0.79 0.98 [0.86–1.12] G/G 1.00 [ref] G/A 1.00 [0.87–1.15] A/A 0.74 [0.36–1.52]
LAG3 G>A rs870849 n/a n/a n/a n/a n/a 0.36 3860/4297 0.90 1.00 [0.93–1.06] G/G 1.00 [ref] G/A 1.00 [0.91–1.10] A/A 0.99 [0.86–1.14]
  1. MAF: Minor allele frequency, T: transmitted, NT: not transmitted, TDT: transmission/disequilibrium test P value, RR: relative risk, 95% CI: 95% confidence intervals, OR: odds ratio, N: number, n/a: not attempted