Table 5 Estimation of age of polymorphism fixation.

SNP

Allele

Number of Disease Chromosomes*

Number of Healthy Chromosomes*

Frequency (disease chromosome)

Frequency (healthy chromosome)

Recombination Fraction

Age Estimate (generations)

R50C

C

12

12

1

1

NA

Q604E

G

2

1

0.167

0.083

0.058833

17.7

5'UTR-19

T

11

10

0.917

0.833

0.033059

9.1

D19H

G

12

12

1

1

NA

NA

INT1-21

C

12

7

1

0.583

0.005

0

INT1-7

C

11

11

0.917

0.917

NA

C54Y

A

9

5

0.75

0.417

0.02749

8.8

E238L

G

12

12

1

1

NA

T400K

A

10

3

0.833

0.25

0.0002

2387

INT10-50

T

12

12

1

1

NA

A565A

C

12

12

1

1

NA

G575R

G

12

12

1

1

NA

A632V

C

11

10

0.917

0.833

0.005692

52.9