Table 1 Characteristics of subjects in the groups selected for low and high lumbar spine bone mineral density.
From: Association between a variation in the phosphodiesterase 4D gene and bone mineral density
| Â | Discovery (UK) | Replication (AUS) | Replication (AUS) | |||
|---|---|---|---|---|---|---|
| Â | Females | Females | Males | |||
Trait | Low BMD (N = 319) | High BMD (N = 321) | Low BMD (N = 138) | High BMD (N = 138) | Low BMD (N = 34) | High BMD (N = 34) |
Age (years) | 48/52/60 | 48/53/59 | 44/52/61 | 45/53/61 | 48/56/65 | 48/54/62 |
Menopausal status | Â | Â | Â | Â | Â | Â |
   Pre | 29% (76) | 31% (84) | 41% (45) | 36% (41) | N/A | N/A |
   Post | 71% (184) | 69% (190) | 59% (66) | 64% (73) |  |  |
Smoking | Â | Â | Â | Â | Â | Â |
   Never | 56% (177) | 53% (168) | 78% (93) | 67% (93) | 41% (14) | 62% (21) |
   Former | 26% (82) | 29% (93) | 22% (13) | 20% (28) | 47% (16) | 21% (7) |
   Current | 18% (56) | 18% (57) | 10% (13) | 13% (17) | 12% (4) | 18% (6) |
Weight (kg) | 58/66/74 | 58/64/72 | 56/64/74 | 58/67/76 | 72/80/87 | 74/80/90 |
BMI | 23/25/28 | 22/25/27 | 22/25/27 | 23/26/29 | 24/27/28 | 24/26/29 |
BMD spine (g/cm2) | 0.74/0.80/0.87 | 1.12/1.19/1.26 | 0.77/0.87/0.96 | 0.98/1.10/1.17 | 0.88/0.92/1.03 | 1.00/1.14/1.21 |
Adjusted BMD spine (g/cm2) | 0.77/0.81/0.84 | 1.14/1.18/1.23 | 0.80/0.84/0.87 | 1.08/1.13/1.19 | 0.86/0.90/0.93 | 1.15/1.17/1.25 |
BMD hip (g/cm2) | 0.75/0.82/0.89 | 0.95/1.02/1.10 | 0.79/0.87/0.95 | 0.91/0.97/1.06 | 0.96/1.03/1.11 | 1.02/1.08/1.20 |
BMD femoral neck (g/cm2) | 0.63/0.70/0.77 | 0.82/0.89/0.98 | 0.64/0.73/0.81 | 0.75/0.84/0.91 | 0.77/0.83/0.92 | 0.80/0.88/0.99 |
BMD forearm (g/cm2) | 0.48/0.52/0.56 | 0.55/0.59/0.61 | 0.49/0.53/0.57 | 0.53/0.56/0.59 | 0.59/0.62/0.68 | 0.64/0.67/0.73 |