Figure 2

Association fine mapping of PDE4D region. Eighty public domain SNPs in a 100-kb window around the initial marker SNP (indicated as a bold symbol at the center of the plot) were compared between the UK low and high BMD pools. Ten of 80 SNPs were significant at P = 0.05 (horizontal dashed line). The x-axis corresponds to the chromosomal position of each SNP, the y-axis to the test P-values (--log₁₀ scale). The continuous dark line presents the results of a goodness-of-fit test for an excess of significant associations (at a 5% significance level) in a 10-kb sliding window assessed at 1-kb increments. The continuous light gray line is the result of a nonlinear smoothing function showing a weighted average of the P-values across the region. The color of each point corresponds to the minor allele frequency of each SNP in the control sample (see legend below graph). Vertical dashed lines are placed every 20 kb. The LocusLink gene annotation for NCBI genome build 34 shows the location of exon six. All investigated SNPs are located within introns.