TY - JOUR AU - Ukena, Sya N. AU - Westendorf, Astrid M. AU - Hansen, Wiebke AU - Rohde, Manfred AU - Geffers, Robert AU - Coldewey, Sina AU - Suerbaum, Sebastian AU - Buer, Jan AU - Gunzer, Florian PY - 2005 DA - 2005/12/13 TI - The host response to the probiotic Escherichia coli strain Nissle 1917: Specific up-regulation of the proinflammatory chemokine MCP-1 JO - BMC Medical Genetics SP - 43 VL - 6 IS - 1 AB - The use of live microorganisms to influence positively the course of intestinal disorders such as infectious diarrhea or chronic inflammatory conditions has recently gained increasing interest as a therapeutic alternative. In vitro and in vivo investigations have demonstrated that probiotic-host eukaryotic cell interactions evoke a large number of responses potentially responsible for the effects of probiotics. The aim of this study was to improve our understanding of the E. coli Nissle 1917-host interaction by analyzing the gene expression pattern initiated by this probiotic in human intestinal epithelial cells. SN - 1471-2350 UR - https://doi.org/10.1186/1471-2350-6-43 DO - 10.1186/1471-2350-6-43 ID - Ukena2005 ER -