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Table 3 Associations between haplotypes in the AIB Phase II group with daytime systolic blood pressure and in the CVD group with hypertension status.

From: Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians

 

AIB Phase II group

CVD group

Haplotypes

Freq

Haplotype scoreb

p-value

Haplotype scoreb*

p-value*

Hypertensive freq

Non-hypertensive freq

Haplotype scoreb

p-value

Haplotype scoreb†

p-value†

EVEa

50.5%

0.497

0.62

0.392

0.70

53.5%

54.4%

-0.578

0.56

-0.715

0.47

KVGa

22.0%

0.638

0.52

0.629

0.51

18.0%

17.8%

0.206

0.84

0.433

0.66

KVEa

21.2%

-0.669

0.50

-0.687

0.49

21.5%

21.7%

-0.004

0.99

-0.073

0.94

EMEa

6.3%

-0.954

0.34

-0.725

0.45

7.0%

6.1%

0.921

0.36

0.948

0.34

Overall p-value

 

0.65

0.73

  

0.80

0.79

  1. a haplotypes defined for positions 158, 257 and 308 respectively
  2. b from the haplo.score method[30]
  3. * Adjusted for age, sex and alcohol intake
  4. † Adjusted for age and sex