Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension

Table 4 Urinary potassium excretion and relation to plasma renin and aldosterone levels

	Carriers of the ENaC variants				Non-carriers	P-values
	βENaC i12-17CT (n = 14)	βENaC G589S (n = 7)	γENaC V546I (n = 5)	All (n = 26)	(n = 236)	All variants versus non-carriers
dU-K (mmol)	86 (68–112)	85 (66–120)	80 (70–96)	83 (68–102)	79 (65–94)	0.23
dU-K/PRA upright	54 (31–122)	57 (38–180)	97 (43–274)	56 (35–129)	38 (23–84)	0.034
dU-K/PRA mean	67 (37–168)	77 (55–252)	107 (59–321)	74 (46–170)	51 (31–118)	0.048
dU-K/Aldo upright	0.15 (0.06–0.25)	0.10 (0.07–0.15)	0.08 (0.06–0.25)	0.10 (0.07–0.21)	0.08 (0.06–0.14)	0.108

Data is given as median (interquartile range). dU-K, daily urinary potassium excretion; PRA, plasma renin activity (μg/L/h); Aldo, serum aldosterone concentration (pmol/L); PRA mean, average of supine and upright PRA.

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