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Table 2 Demographic and clinical features of the hypertensive subjects, according to their ENaC variant status

From: Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension

  Carriers of the ENaC variants Non-carriers
  βENaC i12-17CT (n = 16) βENaC G589S (n = 8) γENaC V546I (n = 8) All (n = 32) (n = 315)
Female/male (n) 9/7 4/4 7/1 20/12 166/149
Age (y) 49.4 ± 8.5 49.3 ± 5.8 50.5 ± 9.0 49.7 ± 7.8 49.3 ± 10.2
BMI (kg/m2) 28.0 ± 4.9 28.2 ± 4.8 27.9 ± 3.8 28.0 ± 4.5 27.4 ± 4.9
Serum creatinine (μmol/L) 88 ± 18.9 91 ± 12.8 85 ± 17.1 88 ± 6.7 88 ± 15.1
Serum uric acid (μmol/L) 329 ± 95.3 335 ± 65.6 386 ± 173.2 338 ± 87.1 340 ± 91.2
Fasting blood glucose (mmol/L) 5.3 ± 0.9 5.7 ± 1.1 5.5 ± 0.9 5.4 ± 0.9 5.6 ± 1.1
Serum cholesterol (mmol/L) 5.5 ± 0.8 6.0 ± 1.2 5.3 ± 0.7 5.6 ± 0.9 5.6 ± 1.0
Serum potassium (mmol/L) 4.1 ± 0.3 4.2 ± 0.4 4.2 ± 0.5 4.2 ± 0.4 4.1 ± 0.3
Serum sodium (mmol/L) 141 ± 2.4 140 ± 3.5 138 ± 2.2 140 ± 2.8 140 ± 0.3
Potassium supplementation (n) 1 0 2 3 (9.4%) 31 (9.8%)
Cerebrovascular disorder (n) 1 0 0 1 (3.1%) 17 (5.4%)
Diabetes (n) 1 1 1 3 (9.4%) 36 (11.4%)
Gestational hypertension (n) 3 1 2 6 (18.8%) 44 (14.0%)
  1. Data for age, creatinine, uric acid, glucose, cholesterol, potassium and sodium is given as mean ± SD. Carriers of the ENaC variants did not differ significantly from non-carriers.