Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans

BMC Medical Genetics

Table 2 IFP1 Variation and Association with Type 2 Diabetes

Name	Variat	dbSNP	Posit	Popul	Frequency, Caucasian		Frequency, Af. American
					Cases	Controls	Cases	Controls
SNP1	C/T	------	-3766	AA/Cauc	0.183 (0.143, 0.223)	0.192 (0.152, 0.232)	0.144 (0.118,0.170)	0.210¹ (0.167,0.253)
SNP3	T/C	rs2293942	-2890	Cauc	0.278 (0.232, 0.324)	0.249 (0.206, 0.292)	------	------
SNP4	A/T	rs2293943	-2877	AA/Cauc	0.339 (0.291, 0.387)	0.369 (0.321,0.417)	0.289 (0.255,0.323)	0.370² (0.321,0.419)
SNP6	G/T	------	-1263	AA/Cauc	0.196 (0.156, 0.236)	0.189 (0.151, 0.229)	0.119 (0.091,0.147)	0.129 (0.093, 0.165)
SNP5	C/T	rs4002827	-992	AA	------	------	0.071 (0.048, 0.094)	0.044 (0.021, 0.067)
SNP2	G/A	------	-279	AA/Cauc	0.458 (0.408, 0.508)	0.429 0.379, 0.479)	0.114 (0.086, 0.142)	0.139 (0.101, 0.177)
SNP11	(G)₄/(G)₃	------	-108	AA/Cauc	0.182 (0.143, 0.221)	0.177 (0.138, 0.216)	0.134 (0.108, 0.160)	0.217³ (0.175, 0.259)
SNP8	G/T	rs4430606	+918	AA/Cauc	0.197 (0.157, 0.237)	0.191 (0.152, 0.232)	0.115 (0.087, 0.143)	0.133 (0.096, 0.170)
InsCCG243	InsCCG	------	+4437	AA	-----	-----	0.091 (0.069, 0.113)	0.060⁴ (0.035, 0.085)

Name, name from Figure 1 and text; variant, major/minor allele except for InsCCG243, in which the insertion is the minor allele; dbSNP, catalog number in public database if available; position, location relative to ATG start; Populat, population in which variant was detected, AA is African American, Cauc is Caucasian; frequency, minor allele frequency. Frequencies are shown with 95% confidence intervals in parentheses. Significance by Fisher Exact test: ¹p = 0.007;²p = 0.008; ³p = 0.0008; ⁴p = 0.088; simulated p values based on 10,000 replicates were 0.027, 0.029, 0.002, and 0.28, for SNP1, SNP4, SNP11, and InsCCG243, respectively. No other simulated p values approached significance.

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