TY - JOUR AU - Graziano, Claudio AU - Giorgi, Massimo AU - Malentacchi, Cecilia AU - Mattiuz, Pier Luigi AU - Porfirio, Berardino PY - 2005 DA - 2005/10/04 TI - Sequence diversity within the HA-1 gene as detected by melting temperature assay without oligonucleotide probes JO - BMC Medical Genetics SP - 36 VL - 6 IS - 1 AB - The minor histocompatibility antigens (mHags) are self-peptides derived from common cellular proteins and presented by MHC class I and II molecules. Disparities in mHags are a potential risk for the development of graft-versus-host disease (GvHD) in the recipients of bone marrow from HLA-identical donors. Two alleles have been identified in the mHag HA-1. The correlation between mismatches of the mHag HA-1 and GvHD has been suggested and methods to facilitate large-scale testing were afterwards developed. SN - 1471-2350 UR - https://doi.org/10.1186/1471-2350-6-36 DO - 10.1186/1471-2350-6-36 ID - Graziano2005 ER -